3-(4-甲酰基苯基)丙酸乙酯合成路线 （共 8 条）
反应条件
lithium hydroxide; water in tetrahydrofuran T=50°C; 3 h;
参考文献
Giannini, Giuseppe; Marzi, Mauro; Pezzi, Riccardo; Brunetti, Tiziana; Battistuzzi, Gianfranco; Marzo, Maria Di; Cabri, Walter; Vesci, Loredana; Pisano, Claudio
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2346 - 2349
反应条件
tributyl-amine; tetrabutyl-ammonium chloride; palladium diacetate in N,N-dimethyl-formamide
T=90°C; Heck reaction;
参考文献
Giannini, Giuseppe; Marzi, Mauro; Pezzi, Riccardo; Brunetti, Tiziana; Battistuzzi, Gianfranco; Marzo, Maria Di; Cabri, Walter; Vesci, Loredana; Pisano, Claudio
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2346 - 2349
反应条件
tetrabutyl-ammonium chloride; triethylamine; palladium diacetate in N,N-dimethyl-formamide
T=90°C; 16 h;
参考文献
Wong, Norman C.W.; Tucker, Joseph E.L.; Hansen, Henrik C.; Chiacchia, Fabrizio S.; McCaffrey, David
Patent: US2008/188467 A1, 2008 ;
Location in patent: Page/Page column 42 ;
US 20080188467 A1
反应条件
hydrogen; platinum on carbon in tetrahydrofuran
T=20°C;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1609798 A1, 2005 ;
Location in patent: Page/Page column 64 ;
反应条件
1: 3-(bromo)propionic acid ethyl ester With indium; copper(l) iodide; lithium chloride in tetrahydrofuran
T=65°C; 12 h;
2: 4-bromo-benzaldehyde With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide
T=90°C; 24 h;
参考文献
Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Wong, Colin Hong An; Yang, Yong-Sheng; Lai, Yin-Chang; Cheong, Hao-Lun; Loh, Teck-Peng
Chemical Communications, 2011 , vol. 47, # 16 p. 4778 - 4780
反应条件
1: 3-(bromo)propionic acid ethyl ester With indium; copper(l) iodide; lithium chloride in tetrahydrofuran
T=65°C; 12 h;
2: 4-chlorobenzaldehyde With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide
T=90°C; 24 h;
参考文献
Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Wong, Colin Hong An; Yang, Yong-Sheng; Lai, Yin-Chang; Cheong, Hao-Lun; Loh, Teck-Peng
Chemical Communications, 2011 , vol. 47, # 16 p. 4778 - 4780
反应条件
1: ethyl 3-(4-bromophenyl)-propionate With n-butyllithium; 2-Bromo-1,3,5-trimethyl-benzene in tetrahydrofuran
2: With n-butyllithium in tetrahydrofuran; n-heptane
3: N,N-dimethyl-formamide in tetrahydrofuran; n-heptane
参考文献
Yamamoto, Yuhei; Maeda, Kenji; Tomimoto, Koji; Mase, Toshiaki
Synlett, 2002 , # 4 p. 561 - 564
反应条件
1: With lithium aluminium tetrahydride in diethyl ether
T=0°C; 1 h; Heating / reflux;
2: With sodium hydroxide in water
T=20°C; 0.166667 h;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1609798 A1, 2005 ;
Location in patent: Page/Page column 64 ;
