(甲氧基甲基)二苯基磷氧合成路线 （共 33 条）
反应条件
1: chloro-diphenylphosphine With AlCl3, aluminium chloride T=50°C; 0.5 h; Inert atmosphere; 2: 2-methoxyacetic acid T=80°C; 4 h; 3: With sodium hydroxide in water
参考文献
STRAITMARK HOLDING AG; BURCK, Sebastian, R., W.; NOTTÉ, Patrick
Patent: WO2013/17564 A2, 2013 ;
Location in patent: Page/Page column 48; 49 ;
反应条件
1: in chloroform T=20°C; Michaelis-Arbuzov reaction; 5.5 h; 2: With sodium hydroxide T=0 - 100°C; 10 h; Further stages.;
参考文献
Morita, Hiroyuki; Tashiro, Shintaro; Takeda, Masahiro; Fujimori, Ken; Yamada, Nobuhiko; Chanmiya Sheikh; Kawaguchi, Hiroyuki
Tetrahedron, 2008 , vol. 64, # 16 p. 3589 - 3595
反应条件
1: diphenylphosphine oxide With methanesulfonic acid; phosphorous pentoxide 0.5 h; 2: 2-methoxyacetic acid 6 h;
参考文献
STRAITMARK HOLDING AG; BURCK, Sebastian R., W.; COGELS, Samuel, Corentin; NOTTE, Patrick
Patent: WO2012/98255 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
air; potassium tert-butylate in dimethyl sulfoxide 2 h;
参考文献
Ngwendson, Julius N.; Schultze, Cassandra M.; Bollinger, Jordan W.; Banerjee, Anamitro
Canadian Journal of Chemistry, 2008 , vol. 86, # 7 p. 668 - 675
反应条件
in dichloromethane 1.) 0 deg C, 1 h, 2.) 20 deg C, 14 h;
参考文献
Maleki, Mehran; Miller, Allen; Lever, O. William Jr.
Tetrahedron Letters, 1981 , vol. 22, p. 365 - 368
参考文献
Aguiar,A.M. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 2383 - 2387
参考文献
Hellmann,H.; Bader,J.
Tetrahedron Letters, 1961 , p. 724 - 729
参考文献
Earnshaw,C. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 3099 - 3106
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Botteghi,C. et al.
Synthetic Communications, 1976 , vol. 6, p. 549 - 554
反应条件
2: aq. NaOH View Scheme
参考文献
Earnshaw,C. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 3099 - 3106
反应条件
in tetrahydrofuran T=20°C; Substitution; 2 h;
参考文献
Cardellicchio, Cosimo; Fracchiolla, Giuseppe; Naso, Francesco; Tortorella, Paolo; Holody, Wieslawa; Michal Pietrusiewicz
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5773 - 5776
