2,4,5-三氟苯甲酸合成路线

参考文献

PROSIDION LIMITED
Patent: WO2007/3960 A1, 2007 ;
Location in patent: Page/Page column 32 ;
WO 2007/003960 A1

446-17-32,4,5-三氟苯甲酸

20372-66-12,4,5-三氟苯甲酸甲酯

参考文献

Terauchi, Hideo; Tanitame, Akihiko; Tada, Keiko; Nishikawa, Yoshinori
Heterocycles, 1996 , vol. 43, # 8 p. 1719 - 1734

446-17-32,4,5-三氟苯甲酸

189025-00-1

参考文献

Ellsworth, Edmund Lee; Kerschen, James Alan; Powell, Sharon Anne; Sanchez, Joseph Peter; Showalter, Howard Daniel Hollis; Stier, Michael Andrew; Tran, Tuan Phong
Patent: US2003/114666 A1, 2003 ;

24424-99-5二碳酸二叔丁酯+

446-17-32,4,5-三氟苯甲酸

182875-05-4

参考文献

PFIZER LIMITED; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan
Patent: WO2013/88315 A1, 2013 ;
Location in patent: Page/Page column 70 ;

446-17-32,4,5-三氟苯甲酸+

75-65-0叔丁醇

182875-05-4

参考文献

PFIZER LIMITED; BROWN, Alan Daniel; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan
Patent: WO2012/7869 A2, 2012 ;
Location in patent: Page/Page column 103-104 ;

446-17-32,4,5-三氟苯甲酸

88419-56-12,4,5-三氟苯甲酰氯

参考文献

Dubar, Faustine; Anquetin, Guillaume; Pradines, Bruno; Dive, Daniel; Khalife, Jamal; Biot, Christophe
Journal of Medicinal Chemistry, 2009 , vol. 52, # 24 p. 7954 - 7957

79-37-8草酰氯+

446-17-32,4,5-三氟苯甲酸

88419-56-12,4,5-三氟苯甲酰氯

参考文献

American Cyanamid Company
Patent: US4940710 A1, 1990 ;

446-17-32,4,5-三氟苯甲酸

98349-24-72,4,5-三氟苯甲酰乙酸乙酯

参考文献

Chu, Daniel T. W.; Nordeen, Carl W.; Hardy, Dwight J.; Swanson, Robert N.; Giardina, William J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 168 - 174

1071-46-1丙二酸单乙酯+

446-17-32,4,5-三氟苯甲酸

98349-24-72,4,5-三氟苯甲酰乙酸乙酯

参考文献

Renau, Thomas E.; Sanchez, Joseph P.; Shapiro, Martin A.; Dever, Julie A.; Gracheck, Stephen J.; Domagala, John M.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2974 - 2977

446-17-32,4,5-三氟苯甲酸

98105-99-8沙拉沙星

参考文献

Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2974 - 2977