反应条件
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 3 h / 60 °C 2.1: magnesium chloride; triethylamine / toluene; tetrahydrofuran / 1 h / 0 - 50 °C / |Large scale 3.1: 0.5 h / 140 °C 3.2: 12 h / 140 °C 4.1: 1-methyl-pyrrolidin-2-one / acetonitrile / 1 h / |Large scale 5.1: 1-methyl-pyrrolidin-2-one; lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / 3.67 h / 23 - 35 °C 6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 23 °C 7.1: 1 h / 35 °C / |Large scale 8.1: 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione / dichloromethane / 1.5 h / 5 °C 9.1: isopropyl alcohol; water / 50 °C View Scheme
参考文献
Barnes, David M.; Christesen, Alan C.; Engstrom, Kenneth M.; Haight, Anthony R.; Hsu, Margaret C.; Lee, Elaine C.; Peterson, Matthew J.; Plata, Daniel J.; Raje, Prasad S.; Stoner, Eric J.; Tedrow, Jason S.; Wagaw, Seble
Organic Process Research and Development, 2006 , vol. 10, # 4 p. 803 - 807
