反应条件
1.1: ethanol / Reflux
2.1: nitric acid; sulfuric acid / 72 h / 0 - 100 °C
3.1: sodium / 0.17 h / Inert atmosphere
3.2: 3 h / Inert atmosphere; Reflux
4.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux
View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; ZHANG, Weihan; SU, Wei-Guo; YANG, Haibin; CUI, Yumin; REN, Yongxin; YAN, Xiaoqiang
Patent: WO2012/356 A1, 2012 ;
WO 2012/000356 A1