2,4-二氟-1-硝基苯合成路线 （共 113 条）
反应条件
dimethylphenylsilane; bis(1,2-diphenylphosphino)benzene; potassium tert-butylate; copper(l) chloride in tetrahydrofuran 12 h; Inert atmosphereReflux; Overall yield = 76 percentSpectr.; regioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 11 p. 3203 - 3207
Angew. Chem., , vol. 125, # 11 p. 3285 - 3289,5
反应条件
1: 90 percent / K2CO3 / acetonitrile / 12 h / Heating 2: 56 percent / H2 / Pd/C / methanol / 12 h / 2068.59 Torr View Scheme
参考文献
Davey; Erhardt; Cantor; Greenberg; Ingebretsen; Wiggins
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2671 - 2677
反应条件
1: iron; aqueous NH4Cl 2: phosphoric acid; sulfuric acid; sodium nitrite / Reagens 4: Harnstoff, anschliessendes Behandeln mit wss. Kaliumjodid-Loesung View Scheme
参考文献
Nad' et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959 , p. 71,73; engl. Ausg. S. 64, 66
反应条件
potassium carbonate in acetone T=65°C; 24 h;
参考文献
Liang, Wu; Liu, Gang
Chinese Journal of Chemistry, 2011 , vol. 29, # 5 p. 983 - 990
反应条件
1: HNO3+H2SO4
View Scheme
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
tert-butoxide in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2005/35520 A1, 2005 ;
Location in patent: Page/Page column 72-74 ;
反应条件
in ammonia
T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
in ammonia
T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
potassium carbonate in tetrahydrofuran; dichloromethane
T=20°C;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2007/203125 A1, 2007 ;
Location in patent: Page/Page column 37 ;
反应条件
1: 63 percent / triethylamine / ethanol / 6 h / Heating
2: H2 / Pd/C / ethanol
3: ethanol / 24 h / Ambient temperature
4: MnO2 / acetone / 0.33 h / Ambient temperature
5: aq. HCl; acetone / 0.33 h
6: para-toluenesulfonic acid / toluene / Heating
View Scheme
参考文献
Dostert; Langlois; Guerret; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 199 - 205
