2,4-二氟-1-硝基苯合成路线 （共 113 条）
反应条件
1: HNO3+H2SO4
2: alcoholic ammonia
View Scheme
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
1: 58 percent / benzene / 20 h / Heating
2: Sn, conc. aq. HCl / ethanol / 1.5 h / Heating
3: 30percent aq H2O2, 8percent aq. NaOH / 0.25 h / Heating
4: POCl3 / dimethylformamide / 1.5 h / Heating
View Scheme
参考文献
Lumma Jr.; Hartman; Saari; Engelhardt; Lotti; Stone
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 93 - 101
反应条件
tetrabutyl ammonium fluoride in acetonitrile
T=25°C; 5 h; Microwave irradiation;
参考文献
Liu, Chuanzhi; Zang, Xufeng; Yu, Baohua; Yu, Xiaochun; Xu, Qing
Synlett, 2011 , # 8 art. no. W03511ST, p. 1143 - 1148
