2,4-二氟-1-硝基苯合成路线 （共 113 条）
反应条件
dimethylphenylsilane; bis(1,2-diphenylphosphino)benzene; potassium tert-butylate; copper(l) chloride in tetrahydrofuran 12 h; Inert atmosphereReflux; Overall yield = 76 percentSpectr.; regioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 11 p. 3203 - 3207
Angew. Chem., , vol. 125, # 11 p. 3285 - 3289,5
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
1: iron; aqueous hydrochloric acid 2: aqueous H2SO4 / Diazotization.Erwaermen der Diazoniumsalz-Loesung auf 90grad View Scheme
参考文献
Chemische Berichte, , vol. 70, p. 2396,2400
反应条件
sulfuric acid; bromine; fluorine Ambient temperature;
参考文献
BNFL Fluorochemicals Ltd
Patent: US5734073 A1, 1998 ;
反应条件
1: 96 percent / NH4OH / 1-methyl-pyrrolidin-2-one / 24 h / 20 °C 2: 98 percent / H2 / Pd/C / ethyl acetate / 12 h / 20 °C / 3361.46 - 3620.04 Torr View Scheme
参考文献
Back, Jong-Beom; Harris, Frank W.
Macromolecules, 2005 , vol. 38, # 2 p. 297 - 306
反应条件
1: HNO3+H2SO4 2: alcohol; ammonia View Scheme
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
sulfuric acid; nitric acid
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
potassium tert-butylate in 1,4-dioxane T=60°C; 0.166667 h; Inert atmosphere; regioselective reaction;
参考文献
Ouellet, Stephane G.; Bernardi, Anna; Angelaud, Remy; O'Shea, Paul D.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3776 - 3779
反应条件
in ammonia T=-70°C; 0.0833333 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
