2,4-二氟-1-硝基苯合成路线 （共 113 条）
反应条件
1: dimethylformamide / 20 °C 2: 73 percent / MgCl2*6H2O / N,N-dimethyl-acetamide / 20 h / 140 - 150 °C View Scheme
参考文献
Gurjar; Reddy; Murugaiah
Synthesis, 2000 , # 12 p. 1659 - 1661
反应条件
calcium hydroxide powder; potassium hydroxide; sulfuric acid in water
参考文献
Hoechst Aktiengesellschaft
Patent: US5227535 A1, 1993 ;
反应条件
lithium hydroxide in water
参考文献
Hoechst Aktiengesellschaft
Patent: US5227535 A1, 1993 ;
反应条件
in various solvent(s) T=20°C; 7.5 h; Title compound not separated from byproducts;
参考文献
DuPont Pharmaceuticals Company
Patent: US6339099 B1, 2002 ;
Location in patent: Page column 105, 106 ;
反应条件
in tetrahydrofuran T=165°C;
参考文献
O'Brien, Alexander G.; Horvath, Zoltan; Levesque, Francois; Lee, Ju Weon; Seidel-Morgenstern, Andreas; Seeberger, Peter H.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 28 p. 7028 - 7030
反应条件
1: 73 percent / NaH / tetrahydrofuran / 20 °C 2: 51 percent / NaH / 20 - 60 °C View Scheme
参考文献
Selvakumar; Azhagan, A.Malar; Srinivas; Krishna, G.Gopi
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9175 - 9178
反应条件
1: 1.81 g / tetrahydrofuran / 2 h / 20 °C 2: 8.4 percent / H2 / Pd/C / methanol / 2.5 h / 2327.17 Torr View Scheme
参考文献
Patil, Sudhakar G.; Bagul, Rahul R.; Swami, Mangesh S.; Kotharkar, Nandini; Darade, Kalpana
Chinese Chemical Letters, 2011 , vol. 22, # 8 p. 883 - 886
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
