2,4-二氟-1-硝基苯合成路线 （共 113 条）
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
ammonia T=25°C; Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 76, # 9 p. 3286 - 3295
反应条件
1.1: tetrahydrofuran / 1 h / -78 °C 1.2: 3 h / -78 - 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran / 2 h View Scheme
参考文献
PLEXXIKON, INC.; IBRAHIM, Prabha, N.; SPEVAK, Wayne; CHO, Hanna; SHI, Songyuan; ZHANG, Chao; ZHANG, Ying
Patent: WO2011/63159 A1, 2011 ;
反应条件
1: 1) NaH / 1) DMSO, 100 deg C, 40 min, 2a) RT, 30 min, 2b) 100 deg C, 1 h 2: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C 3: 87 percent / Fe powder / acetic acid / 1 h / 100 °C View Scheme
参考文献
Quallich; Morrissey
Synthesis, 1993 , # 1 p. 51 - 53
反应条件
1: 58 percent / benzene / 20 h / Heating 2: Sn, conc. aq. HCl / ethanol / 1.5 h / Heating 3: 30percent aq H2O2, 8percent aq. NaOH / 0.25 h / Heating View Scheme
参考文献
Lumma Jr.; Hartman; Saari; Engelhardt; Lotti; Stone
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 93 - 101
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=-40°C; 0.00277778 h; Product distribution;
参考文献
Makosza, Mieczyslaw; Lemek, Tadeusz; Kwast, Andrzej; Terrier, Francois
Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 394 - 400
反应条件
in tetrahydrofuran T=165°C;
参考文献
O'Brien, Alexander G.; Horvath, Zoltan; Levesque, Francois; Lee, Ju Weon; Seidel-Morgenstern, Andreas; Seeberger, Peter H.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 28 p. 7028 - 7030
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Large scale reaction 1.2: 20 °C / Large scale reaction 1.3: 10 °C / pH 4 - 5 / Large scale reaction 2.1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction 3.1: methanol / 30 - 35 °C / Large scale reaction 4.1: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction View Scheme
参考文献
Huang, Yun-Sheng; Zhang, Wen-Qing; Zhang, Xu; Wang, Jian-Zhong
Research on Chemical Intermediates, 2010 , vol. 36, # 8 p. 975 - 983
