1: 2-nitro-5-hydroxy-1-fluorobenzene With N-ethyl-N,N-diisopropylamine in methanol; acetonitrile T=0°C; 0.5 h; 2: diazomethyl-trimethyl-silane With methanol in acetonitrile T=20°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 69 ;