2,4,5-三甲氧基苯甲醛合成路线 （共 90 条）
反应条件
1.1: magnesium / diethyl ether / 2 h 1.2: 78 percent / diethyl ether; toluene / 20 °C 2.1: 68 percent / silica gel / dioxane / 0.05 h / microwave irradiation View Scheme
参考文献
Diaz, Francisco; Contreras, Leticia; Flores, Rosa; Tamariz, Joaquin; Labarrios, Fernando; et al.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 133 - 138
反应条件
peracetic acid; perchloric acid; acetic anhydride
参考文献
Huee,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3617 - 3624
反应条件
1: BCl3 2: K2CO3 View Scheme
参考文献
Jackson,A.H.; Martin,J.A.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 2222 - 2229
反应条件
1: mCPBA / 2 h / Ambient temperature 2: aq. KOH / ethanol / 2 h / 50 °C 3: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature 4: 1.) HMPA, n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, then -40 to -10 deg C, 1 h, -10 deg C, 1h, 2.) THF, hexane, overnight 5: 35 percent / ammonium cerium(IV) nitrate / acetonitrile; H2O / 1.) -7 deg C, 1 h, 2.) room temp., 2 h View Scheme
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZONA STATE UNIVERSITY; MADATHIL, Manikandadas, Mathilakathu; KHDOUR, Omar; HECHT, Sidney
Patent: WO2014/59158 A1, 2014 ;
反应条件
1: 88 percent / 1 h / 160 °C 2: 1) 1.0 M borane/THF complex 2) HCl / 1) THF, reflux, 3 h 2) CH2Cl2 View Scheme
参考文献
Swenton, John S.; Shih, Chuan; Chen, Chung-Pin; Chou, Chun-Tzer
Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2019 - 2026
反应条件
1: 88 percent / 1 h / 160 °C 2: 1) 1.0 M borane/THF complex 2) HCl / 1) THF, reflux, 3 h 2) CH2Cl2 3: 88 percent / pyridine / Ambient temperature 4: 68 percent / 1) 2percent KOH 2) H2O / Ambient temperature; anodic oxidation; other substrates 5: 75 percent / p-TsOH*H2O / benzene / 0.5 h / 60 °C View Scheme
参考文献
Swenton, John S.; Shih, Chuan; Chen, Chung-Pin; Chou, Chun-Tzer
Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2019 - 2026
反应条件
1: 73 percent / diethyl ether; toluene / 20 °C 2: 48 percent / silica gel / dioxane / 0.18 h / microwave irradiation View Scheme
参考文献
Sharma, Anuj; Joshi, Bhupendra P.; Sinha, Arun K.
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 12 p. 2231 - 2235
反应条件
1.1: boron tribromide / dichloromethane / 10 h / 0 °C / |Inert atmosphere 2.1: potassium carbonate / butanone / 0.17 h / 0 °C / |Inert atmosphere 2.2: 4 h / 90 °C / |Inert atmosphere View Scheme
参考文献
Laplace, Duchan R.; Verbraeken, Bart; Van Hecke, Kristof; Winne, Johan M.
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 253 - 262
反应条件
1: hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 0.12 h / Irradiation 2: KOH / bis-(2-hydroxy-ethyl) ether / 0.28 h / Irradiation View Scheme
参考文献
Chattopadhyay, Sarmishtha; Banerjee, Sajal Kumar; Mitra, Alok Kumar
Journal of the Indian Chemical Society, 2002 , vol. 79, # 11 p. 906 - 907
反应条件
pyridine T=60 - 100°C;
参考文献
van Alphen
Recueil des Travaux Chimiques des Pays-Bas, 1928 , vol. 47, p. 174
