2,4,5-三甲氧基苯甲醛合成路线 （共 90 条）
反应条件
sodium hydroxide in water
T=0 - 20°C;
参考文献
Agarwal, Anu; Srivastava, Kumkum; Puri; Chauhan, Prem M.S.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6226 - 6232
反应条件
1: dihydrogen peroxide; sulfuric acid / methanol / 2 h / 20 °C
2: potassium carbonate / acetone / 18 h / 65 °C
3: hydrogen bromide / acetic acid / 6 h / 55 °C
View Scheme
参考文献
Filosa, Rosanna; Peduto, Antonella; Aparoy, Polamarasetty; Schaible, Anja M.; Luderer, Susann; Krauth, Verena; Petronzi, Carmen; Massa, Antonio; De Rosa, Mario; Reddanna, Pallu; Werz, Oliver
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 269 - 279
反应条件
1.1: NaOEt / ethanol / 21 h / Heating
2.1: 3.16 g / K2CO3 / acetone / 20 h / Heating
3.1: LDA / tetrahydrofuran / 0.17 h / -70 °C
3.2: tetrahydrofuran / 1 h / -70 °C
4.1: TFA / 1 h / 20 °C
4.2: 0.798 mg / K2CO3 / acetone / 3.5 h / Heating
5.1: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
6.1: PBr3 / tetrahydrofuran / 1 h / -78 °C
6.2: 72 percent / LiAlH4 / tetrahydrofuran / 1.92 h
7.1: 49 percent / PBr3 / tetrahydrofuran / 1 h / 60 °C
8.1: 99 percent / n-Bu3SnH / toluene / 12 h / Heating
View Scheme
参考文献
Yvon; Datta; Le; Charlton
Synthesis, 2001 , # 10 p. 1556 - 1560
反应条件
1: mCPBA / 2 h / Ambient temperature
2: aq. KOH / ethanol / 2 h / 50 °C
3: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature
4: 1.) HMPA, n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, then -40 to -10 deg C, 1 h, -10 deg C, 1h, 2.) THF, hexane, overnight
5: 1.) ammonium cerium(IV) nitrate, 2.) HClO4 / 1.) CH3CN, H2O, -7 deg C, 1 h, then room temp., 2 h, 2.) CH2Cl2, room temp., 4 h
View Scheme
参考文献
Poigny, Stephane; Guyot, Michele; Samadi, Mohammad
Tetrahedron, 1998 , vol. 54, # 49 p. 14791 - 14802
反应条件
propionic acid sodium salt
T=150°C; im geschlossenen Rohr;
参考文献
Gattermann; Eggers
Chemische Berichte, 1899 , vol. 32, p. 290
参考文献
Gattermann; Eggers
Chemische Berichte, 1899 , vol. 32, p. 290
反应条件
1: With AlCl3, aluminium chloride in dichloromethane
T=20°C; Reflux;
2: With hydrogenchloride in dichloromethane; water
参考文献
Cai, Xueting; Yang, Jie; Zhou, Jinpei; Lu, Wuguang; Hu, Chunping; Gu, Zhenhua; Huo, Jiege; Wang, Xiaoning; Cao, Peng
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 84 - 92
反应条件
aluminium trichloride in dichloromethane
1 h; Ambient temperature;
参考文献
Mali, R. S.; Yadav, V. J.; Zaware, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, p. 759 - 760
反应条件
1: 0.8 g
2: 0.12 g / DDQ
View Scheme
参考文献
Iinuma; Iwashima; Matsuura
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4935 - 4941
反应条件
1.1: 73 percent / AlCl3 / CH2Cl2 / 3 h / 20 °C
2.1: 82 percent / i-Pr2NEt; DMAP / CH2Cl2 / 12 h / 20 °C
3.1: diethyl ether; tetrahydrofuran / 1 h / -30 - 0 °C
3.2: 63 percent / tetrahydrofuran; diethyl ether / -78 - 20 °C
View Scheme
参考文献
Tuttle, Kristin; Rodriguez, Andrew A.; Pettus, Thomas R. R.
Synlett, 2003 , # 14 p. 2234 - 2236
