甲基-2-脱氧-L-赤式戊呋喃糖合成路线 （共 21 条）
反应条件
1.1: 81 percent / HCl / 2 h / Heating 2.1: 100 percent / Amberlyst 15 (H+ form) / dimethylformamide / 18 h / 20 °C 3.1: NaH / tetrahydrofuran / 2 h / Heating 3.2: tetrahydrofuran / 2 h / 20 °C 4.1: 39.62 g / tetrahydrofuran / 16 h / 0 °C 5.1: Ph2SiH; AIBN / dioxane / 18 h / Heating 6.1: 16.36 g / H2O; AcOH / 16 h / 20 °C 7.1: 71.1 percent / H2O; HCl / 72 h / 20 °C 8.1: 81 percent / HCl / 1 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1.1: 100 percent / Amberlyst 15 (H+ form) / dimethylformamide / 18 h / 20 °C 2.1: NaH / tetrahydrofuran / 2 h / Heating 2.2: tetrahydrofuran / 2 h / 20 °C 3.1: 39.62 g / tetrahydrofuran / 16 h / 0 °C 4.1: Ph2SiH; AIBN / dioxane / 18 h / Heating 5.1: 16.36 g / H2O; AcOH / 16 h / 20 °C 6.1: 71.1 percent / H2O; HCl / 72 h / 20 °C 7.1: 81 percent / HCl / 1 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1.1: NaH / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 2 h / 20 °C 2.1: 39.62 g / tetrahydrofuran / 16 h / 0 °C 3.1: Ph2SiH; AIBN / dioxane / 18 h / Heating 4.1: 16.36 g / H2O; AcOH / 16 h / 20 °C 5.1: 71.1 percent / H2O; HCl / 72 h / 20 °C 6.1: 81 percent / HCl / 1 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1: Ph2SiH; AIBN / dioxane / 18 h / Heating 2: 16.36 g / H2O; AcOH / 16 h / 20 °C 3: 71.1 percent / H2O; HCl / 72 h / 20 °C 4: 81 percent / HCl / 1 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
hydrogenchloride; methanol Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 28; 29 ;
反应条件
hydrogenchloride; methanol
参考文献
Deriaz et al.
Journal of the Chemical Society, 1949 , p. 2836,2839
反应条件
1: 71.1 percent / H2O; HCl / 72 h / 20 °C 2: 81 percent / HCl / 1 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
1: 16.36 g / H2O; AcOH / 16 h / 20 °C 2: 71.1 percent / H2O; HCl / 72 h / 20 °C 3: 81 percent / HCl / 1 h / 20 °C View Scheme
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
反应条件
Acidic conditions; Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 20; 21 ;
反应条件
hydrogenchloride T=2°C; Methylation; Product distribution; Further Variations:reaction time;
参考文献
Zhang, Weijian; Ramasamy, Kanda S.; Averett, Devron R.
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2357 - 2365
