2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮合成路线 （共 13 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran 0.666667 h; Reflux; Time; Overall yield = 17.8 g;
参考文献
ZENTIVA, K.S.; HALAMA, Ales; KRULIS, Radim; BRICHAC, Jiri
Patent: WO2013/120464 A1, 2013 ;
Location in patent: Page/Page column 11 ;
反应条件
1: 87 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / 60 °C 2: aq. MeNH2 / ethanol / 1 h / Heating 3: 86 percent / pyridine / 1 h / 20 °C View Scheme
参考文献
APOTEX PHARMACHEM INC.; BODHURI, Prabhudas; WEERATUNGA, Gamini
Patent: WO2012/51692 A1, 2012 ;
反应条件
1.1: tetrahydrofuran / 4 h / |Reflux 2.1: methylamine / ethanol; water / 2 h / 65 °C 2.2: 65 °C / pH 2.7 View Scheme
参考文献
WANBURY LTD.; DR. NITIN SHARADCHANDRA PRADHAN; DR. NILESH SUDHIR PATIL; DR. RAJESH RAMCHANDRA WALAVALKAR; MR. NILESH SUBHAS KULKARNI; MR. SANDIP BABANRAO PAWAR; MR. TARAK SAMBHAJI PAWAR
Patent: WO2014/102820 A2, 2014 ;
