1-苄基-3-苯基哌啶-4-酮合成路线 （共 8 条）
反应条件
1: hydrogenchloride / ethyl acetate 2: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 55 °C / 3800.26 Torr 3: triethylamine / acetonitrile / 14 h View Scheme
参考文献
Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6430 - 6446
反应条件
hydrogenchloride in water; acetic acid
T=120°C; 12 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1553084 A1, 2005 ;
Location in patent: Page/Page column 43 ;
反应条件
1: With hydrogenchloride; water; acetic acid
T=125°C; 5 h;
2: With sodium hydroxide in water
参考文献
Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6430 - 6446
反应条件
in acetonitrile
T=80°C; double aza-Michael reaction; 1.5 h;
参考文献
Rosiak, Anna; Hoenke, Christoph; Christoffers, Jens
European Journal of Organic Chemistry, 2007 , # 26 p. 4376 - 4382
反应条件
1: ethanol; sodium hydride / toluene; mineral oil / 2 h / -5 - 75 °C
2: hydrogenchloride; water; acetic acid / 5 h / 125 °C
View Scheme
参考文献
Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6430 - 6446
反应条件
1: sodium carbonate / acetonitrile / 2 h / 70 °C
2: ethanol; sodium hydride / toluene; mineral oil / 2 h / -5 - 75 °C
3: hydrogenchloride; water; acetic acid / 5 h / 125 °C
View Scheme
参考文献
Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6430 - 6446
反应条件
1: hydrogenchloride / ethyl acetate
2: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 55 °C / 3800.26 Torr
View Scheme
参考文献
Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6430 - 6446
反应条件
1: hydrogenchloride / ethyl acetate
2: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 55 °C / 3800.26 Torr
3: triethylamine / acetonitrile / 14 h
4: hydrogenchloride; hydroxylamine; sodium acetate / ethanol; water / 2 h / 75 °C
5: hydrogen / tetrahydrofuran; ethanol / 2 h / 75 °C
View Scheme
参考文献
Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6430 - 6446
