2-(4-甲基苯基)吡啶合成路线 （共 103 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=65°C; Negishi cross-coupling; 24 h; Inert atmosphere;
参考文献
Luzung, Michael R.; Patel, Jigar S.; Yin, Jingjun
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8330 - 8332
反应条件
1: 2-hydroxy-pyridine With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=100°C; 3 h; Inert atmosphere; 2: p-methylphenylboronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Li, Shui-Ming; Huang, Jie; Chen, Guo-Jun; Han, Fu-She
Chemical Communications, 2011 , vol. 47, # 48 p. 12840 - 12842
反应条件
C52H44CoN4O4; potassium hydroxide; tert-butyl alcohol T=200°C; 6 h; Inert atmosphereDarkness;
参考文献
Tetrahedron Letters, , vol. 53, # 13 p. 1571 - 1575
反应条件
[NiCl2(PMe3)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=70°C; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1641 - 1645
反应条件
C35H31BrN4NiP in tetrahydrofuran T=25°C; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Guo, Wang-Jun; Wang, Zhong-Xia
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 1054 - 1061
反应条件
palladium diacetate; tris-(o-tolyl)phosphine in toluene T=20°C; 5 h; Inert atmosphere;
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine; copper(l) iodide in tetrahydrofuran T=100°C; Suzuki-Miyaura cross-coupling reaction;
参考文献
Hodgson, Paul B.; Salingue, Fabrice H.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 685 - 687
反应条件
PEG 4000; palladium diacetate; potassium carbonate T=120°C; 15 h;
参考文献
Wang, Liang; Zhang, Yuhong; Liu, Leifang; Wang, Yanguang
Journal of Organic Chemistry, 2006 , vol. 71, # 3 p. 1284 - 1287
反应条件
tetrakis(triphenylphosphine) palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=80°C; Heck reaction; 3 h; Molecular sieveInert atmosphere; regioselective reaction;
参考文献
Zhu, Jia-Liang; Chan, Yu-Hui
Synlett, 2008 , # 8 p. 1250 - 1254
反应条件
C68H72Cl2N6NiP2 in diethyl ether T=25°C; Kumada coupling reaction; 12 h; Inert atmosphere;
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Chemistry - A European Journal, 2010 , vol. 16, # 34 p. 10332 - 10336
