4-羟基-3-甲氧基苯乙腈合成路线 （共 28 条）
反应条件
1: 82 percent / H2; HCl / Pd/C / ethanol / 12 h / 20 °C 2: 87 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=20°C; 12 h;
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: (4-hydroxy-3-methoxy-phenyl)-acetonitrile With potassium carbonate in acetone 0.166667 h; 2: benzyl bromide in acetone 4 h; Reflux;
参考文献
Imbri, Dennis; Tauber, Johannes; Opatz, Till
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15080 - 15083
反应条件
1: N-ethyldiisopropylamine / CH2Cl2 / 48 h / Ambient temperature
2: 6.6 aq. N KOH / ethanol / 12 h / Heating
3: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH2Cl2 / 1 h / Ambient temperature
4: 76 percent / SnCl4 / tetrahydrofuran / 1.5 h
View Scheme
参考文献
Appendino, Giovanni; Cravotto, Giancarlo; Palmisano, Giovanni; Annunziata, Rita; Szallasi, Arpad
Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3123 - 3131
反应条件
1: 1.) BH3, HCl; 2.) aqueous NH3
2: 90.4 percent / Heating
3: POCl3 / acetonitrile / Heating
4: NaBH4
View Scheme
参考文献
Rice; Brossi
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 592 - 601
反应条件
1: 82 percent / H2; HCl / Pd/C / ethanol / 12 h / 20 °C
2: 71 percent / 2 h / Heating
View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1.1: potassium carbonate / acetone / 0.17 h
1.2: 4 h / |Reflux
2.1: N-bromosuccinmide; trifluoroacetic acid / acetonitrile / 3 h / 20 °C
View Scheme
参考文献
Imbri, Dennis; Tauber, Johannes; Opatz, Till
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15080 - 15083
反应条件
1: 74 percent / KOH / ethanol / Heating
2: 75 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; p-dimethylaminopyridine / dimethylformamide / 3 h / 20 °C
View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
