2-(2-溴吡啶-4-基)-1-(吡啶-2-基)乙酮合成路线 （共 3 条）
反应条件
1: 2-bromo-4-methyl-pyridine With potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-50°C; 0.5 h; Inert atmosphere;
2: 2-pyridinecarboxylic acid ethyl ester in tetrahydrofuran; toluene
T=-50 - 45°C; Inert atmosphere;
参考文献
Ciayadi, Rudy; Potdar, Mahesh; Walton, Kelly L.; Harrison, Craig A.; Kelso, Geoffrey F.; Harris, Simon J.; Hearn, Milton T.W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5642 - 5645
反应条件
1: acetic acid / dimethylformamide / 1.3 h / 20 °C
2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C
View Scheme
参考文献
Ciayadi, Rudy; Potdar, Mahesh; Walton, Kelly L.; Harrison, Craig A.; Kelso, Geoffrey F.; Harris, Simon J.; Hearn, Milton T.W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5642 - 5645
反应条件
1: acetic acid / dimethylformamide / 1.3 h / 20 °C
2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C
3: 85.3 percent / potassium carbonate / acetone / 24 h / Heating
4: 83.6 percent / aq. Na2CO3; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating
View Scheme
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
