2-(2-溴-4-吡啶)-1-(6-甲基-2-吡啶)乙酮合成路线 （共 3 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
T=-30 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13138 A2, 2004 ;
Location in patent: Page 26 ;
WO 2004/013138 A2
反应条件
1: 2-bromo-4-methyl-pyridine With sodium hexamethyldisilazane in tetrahydrofuran
T=-30°C; 1 h;
2: 5-methylpicolic acid methyl ester in tetrahydrofuran
T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13134 A2, 2004 ;
Location in patent: Page 33 ;
WO 2004/013134 A2
反应条件
1: 2-bromo-4-methyl-pyridine With sodium hexamethyldisilazane in tetrahydrofuran
T=-30°C; 1 h;
2: 6-methyl-2-picolinic acid ethyl ester in tetrahydrofuran
T=-30 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13135 A1, 2004 ;
Location in patent: Page 54 ;
WO 2004/013135 A1
