2-溴-4-[3-(2-吡啶)-1H-吡唑-4-基]吡啶合成路线 （共 4 条）
反应条件
1: acetic acid / dimethylformamide / 1.3 h / 20 °C
2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C
View Scheme
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
反应条件
1.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / -50 °C
1.2: 57 percent / tetrahydrofuran; toluene / 18 h / 20 °C
2.1: acetic acid / dimethylformamide / 1.3 h / 20 °C
3.1: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C
View Scheme
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
反应条件
1.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / -50 °C
1.2: 57 percent / tetrahydrofuran; toluene / 18 h / 20 °C
2.1: acetic acid / dimethylformamide / 1.3 h / 20 °C
3.1: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C
View Scheme
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
反应条件
1: 85.3 percent / potassium carbonate / acetone / 24 h / Heating
2: 83.6 percent / aq. Na2CO3; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating
View Scheme
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
