2-氨基-4-氯-6-甲基嘧啶合成路线 （共 21 条）
参考文献
Schmidt
Chemische Berichte, 1902 , vol. 35, p. 1577
反应条件
1: Ac2O / 120 - 130 °C 2: aq. HCl / ethanol / 2.5 h / (heating) View Scheme
参考文献
Fujita; Yamamoto; Minami; Takamatsu
Chemical and pharmaceutical bulletin, 1965 , vol. 13, # 10 p. 1183 - 1193
反应条件
1: 1.) NaOEt / 1.) ethanol, reflux, 30 min; 2.) ethanol, reflux, 2 h 2: 66 percent / m-chloroperbenzoic acid / CH2Cl2 / Ambient temperature 3: 16 percent / NaH / tetrahydrofuran / 1.5 h / 40 °C View Scheme
参考文献
Yamanaka; Ogawa; Konno
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 98 - 104
反应条件
hydroxylamine hydrochloride; triethylamine in ethanol 1 h; Heating;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 22, # 11 p. 1232 - 1236
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 22, # 11 p. 1523 - 1527
反应条件
potassium carbonate; nitrobenzene
参考文献
Matsukawa et al.
Yakugaku Zasshi, 1950 , vol. 70, p. 283,284
Chem.Abstr., 1951 , p. 2894
反应条件
hydrazine hydrate in various solvent(s) 1 h; Ambient temperature;
参考文献
Crabb, Derek L.; Main, David A.; Morley, John O.; Preston, Peter N.; Wright, Stanley H. B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1997 , # 1 p. 49 - 58
反应条件
hydrogen iodide; sodium iodide in 1,4-dioxane 9 h; Heating;
参考文献
Sugimoto, Osamu; Mori, Miho; Moriya, Keisuke; Tanji, Ken-Ichi
Helvetica Chimica Acta, 2001 , vol. 84, # 5 p. 1112 - 1118
反应条件
1: 65 percent / m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature
2: NaOH / 1 h / 20 - 25 °C
View Scheme
参考文献
Yamanaka; Ogawa; Konno
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 98 - 104
反应条件
hydroxylamine in ethanol
4 h; Heating;
参考文献
Hurst, Derek T.
Heterocycles, 1984 , vol. 22, # 1 p. 79 - 84
反应条件
hydroxylamine hydrochloride; triethylamine in ethanol
1 h; Heating;
参考文献
Moskalenko, G. G.; Sedova, V. F..; Mamaev, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 11 p. 1232 - 1236
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 11 p. 1523 - 1527
