1: 5-[[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphenyl]thio]methyl]-2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methylthiazole With sodium hydroxide in acetone T=30°C; 0.75 h; 2: 1,1,1-trichloro-2-methyl-2-propanol in acetone T=30 - 40°C; 3: With hydrogenchloride; water pH=1; Product distribution / selectivity;

1: 4-[[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenol With sodium hydroxide in acetone T=32°C; 3 h; 2: 1,1,1-trichloro-2-methyl-2-propanol in acetone T=36 - 38°C; 1 h; 3: With hydrogenchloride; water in methyl tert-butyl ether (MTBE); acetone T=25°C; Product distribution / selectivity;

1: 4-[[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenol With sodium hydroxide in butanone T=50°C; 1 h; Inert atmosphereLarge scale reaction; 2: 2-bromo-2-methyl-propionic acid in butanone T=50°C; 3 h; Large scale reaction;

1: in water; ethyl acetate T=77°C; 15 h; 2: With sodium hydroxide in ethanol; water T=60°C; 2 h;