Boc-(4-氨基苯基硫代)乙酸合成路线 （共 4 条）
反应条件
1: With triethylamine in 1,4-dioxane; water
T=20°C; 24 h;
2: With hydrogenchloride
参考文献
Griffin, Roger J.; Henderson, Andrew; Curtin, Nicola J.; Echalier, Aude; Endicott, Jane A.; Hardcastle, Ian R.; Newell, David R.; Noble, Martin E. M.; Wang, Lan-Zhen; Golding, Bernard T.
Journal of the American Chemical Society, 2006 , vol. 128, # 18 p. 6012 - 6013
反应条件
1: N-(tert-butoxycarbonyl)-4-(methylthio)aniline With n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane
T=-75°C; 2 h;
2: carbon dioxide in tetrahydrofuran; hexane
cooling;
参考文献
Cabiddu, Maria Grazia; Cabiddu, Salvatore; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana
Tetrahedron, 2003 , vol. 59, # 16 p. 2893 - 2897
反应条件
1.1: 50 percent / tetrahydrofuran / 60 °C
2.1: potassium tert-butoxide; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 75 percent / tetrahydrofuran; hexane / cooling
View Scheme
参考文献
Cabiddu, Maria Grazia; Cabiddu, Salvatore; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana
Tetrahedron, 2003 , vol. 59, # 16 p. 2893 - 2897
反应条件
1.1: 50 percent / tetrahydrofuran / 60 °C
2.1: potassium tert-butoxide; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 75 percent / tetrahydrofuran; hexane / cooling
View Scheme
参考文献
Cabiddu, Maria Grazia; Cabiddu, Salvatore; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana
Tetrahedron, 2003 , vol. 59, # 16 p. 2893 - 2897
