4-氟-2-硝基乙酰苯胺合成路线 （共 23 条）
反应条件
in dimethyl sulfoxide T=100°C; Substitution; 60 h;
参考文献
Tetrahedron, , vol. 55, # 46 p. 13285 - 13300
反应条件
1: 90 percent / sodium ethoxide / ethanol / 4 h / Heating 2: 1.) aq.hydrochloric acid, NaNO2, 2.) CuCN / 1.) 0-3 deg C, 1 hr., 2.) 80-90 deg C View Scheme
参考文献
Liedholm,B.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976 , vol. 30, p. 141 - 149
反应条件
1: 9 M HCl / 0.5 h / Heating 2: H2 / Raney Ni / ethanol 3: ethanol; H2O / 12 h / Heating View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 9 M HCl / 0.5 h / Heating 2: H2 / Raney Ni / ethanol View Scheme
参考文献
Pujari, H. K.; Sharma, B. R.; Dahiya, Rajender; Kumar, Sudhir; Murakami, Yasuoki; Tani, Masanobu
Journal of Fluorine Chemistry, 1990 , vol. 46, # 2 p. 343 - 355
反应条件
1: 90 percent / sodium ethoxide / ethanol / 4 h / Heating 2: 1.) aq.hydrochloric acid, NaNO2, 2.) CuCN / 1.) 0-3 deg C, 1 hr., 2.) 80-90 deg C 3: 76 percent / 1.) aq.H2SO4, acetic acid, 2.) acetic acid, acetic anhydride / 8 h / 1.) reflux, 8 hrs., 2.) ferlux 15 min., 4: 92 percent / N2H4 (monohydrate) (80 percent), FeCl3 (hexahydrate) / ethanol / 10 h / Heating; active carbon View Scheme
参考文献
Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Pomykacek, Josef; Ryska, Miroslav; et al.
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 3 p. 698 - 722
反应条件
1: (hydrolysis) View Scheme
参考文献
Liedholm,B.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976 , vol. 30, p. 141 - 149
反应条件
1: 90 percent / sodium ethoxide / ethanol / 4 h / Heating 2: 1.) aq.hydrochloric acid, NaNO2, 2.) CuCN / 1.) 0-3 deg C, 1 hr., 2.) 80-90 deg C View Scheme
参考文献
Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Pomykacek, Josef; Ryska, Miroslav; et al.
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 3 p. 698 - 722
反应条件
1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 3: toluene / 2 h / Heating View Scheme
参考文献
Ghosh; Ternai; Whitehouse
Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 255 - 260
反应条件
1: aqueous hydrochloric acid 2: concentrated sulfuric acid; arsenic (V)-oxide View Scheme
参考文献
Wilkinson; Finar
Journal of the Chemical Society, 1948 , p. 288,290
反应条件
1: aqueous hydrochloric acid 2: concentrated sulfuric acid; arsenic (V)-oxide 3: iron; aqueous ethanol; CaCl2 View Scheme
参考文献
Wilkinson; Finar
Journal of the Chemical Society, 1948 , p. 288,290
