2,8,12,18-四乙基-3,7,13,17-四甲基-21H,23H-卟啉合成路线 （共 36 条）
反应条件
1.1: 75 percent / PhCOCl / 0 - 20 °C
2.1: 162 mg / HBr; AcOH / methanol / 0.5 h / 20 °C
3.1: CuCl2 / dimethylformamide / 4 h / 20 °C
3.2: 31 percent / H2SO4; CF3CO2H / 0.75 h / 20 °C
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
1.1: 162 mg / HBr; AcOH / methanol / 0.5 h / 20 °C
2.1: CuCl2 / dimethylformamide / 4 h / 20 °C
2.2: 31 percent / H2SO4; CF3CO2H / 0.75 h / 20 °C
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
1.1: 81 percent / HCl / methanol / 3 h / Heating
2.1: NaOH / ethane-1,2-diol / 1 h / Heating
3.1: 162 mg / HBr; AcOH / methanol / 0.5 h / 20 °C
4.1: CuCl2 / dimethylformamide / 4 h / 20 °C
4.2: 31 percent / H2SO4; CF3CO2H / 0.75 h / 20 °C
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
1: 95 percent / 20 percent NaOH / ethanol / 5 h / Heating
2: 78 percent / ethanolamine / 5 h / 170 °C
3: acetonitrile / 1 h / Ambient temperature
4: 2.) 2,3-dichloro-5,6-dicyano-p-benzoquinone / 1.) MeCN, r.t., 14 h, 2.) MeCN, MeOH, r.t., 30 min
View Scheme
参考文献
Hombrecher, Hermann K.; Horter, Gaby
Liebigs Annalen der Chemie, 1991 , # 3 p. 219 - 227
反应条件
1: 78 percent / ethanolamine / 5 h / 170 °C
2: acetonitrile / 1 h / Ambient temperature
3: 2.) 2,3-dichloro-5,6-dicyano-p-benzoquinone / 1.) MeCN, r.t., 14 h, 2.) MeCN, MeOH, r.t., 30 min
View Scheme
参考文献
Hombrecher, Hermann K.; Horter, Gaby
Liebigs Annalen der Chemie, 1991 , # 3 p. 219 - 227
反应条件
1: acetonitrile / 1 h / Ambient temperature
2: 2.) 2,3-dichloro-5,6-dicyano-p-benzoquinone / 1.) MeCN, r.t., 14 h, 2.) MeCN, MeOH, r.t., 30 min
View Scheme
参考文献
Hombrecher, Hermann K.; Horter, Gaby
Liebigs Annalen der Chemie, 1991 , # 3 p. 219 - 227
反应条件
1: 61 percent / KOH / 8 h / Heating
2: K10 montmorillonite / CH2Cl2 / in the dark; var. reag. HCl, AcOH, NaOAc, pyridine, H2TPP, var.time and temp.
View Scheme
参考文献
Jeandon, C.; Callot, H. J.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 625 - 629
反应条件
1: 97 percent / 20 percent NaOH / ethanol / 5 h / Heating
2: 73 percent / ethanolamine / 5 h / 170 °C
3: 2.) 2,3-dichloro-5,6-dicyano-p-benzoquinone / 1.) MeCN, r.t., 14 h, 2.) MeCN, MeOH, r.t., 30 min
View Scheme
参考文献
Hombrecher, Hermann K.; Horter, Gaby
Liebigs Annalen der Chemie, 1991 , # 3 p. 219 - 227
反应条件
1: ethanolamine / Heating
2: 2.) tetrachloro-o-benzoquinone / 1.) benzene, reflux, 1 h
View Scheme
参考文献
Chang, C. K.; Abdalmuhdi, Ismail
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5388 - 5390
反应条件
1: 3.2 g / 0.5 h / Heating
2: 2.) tetrachloro-o-benzoquinone / 1.) benzene, reflux, 1 h, 2.) room temp., 30 min
View Scheme
参考文献
Chang, C. K.; Abdalmuhdi, Ismail
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5388 - 5390
