乙基5,6,7,8-四氟-2-甲基-4-氧代-4H-苯并吡喃-3-羧酸酯合成路线 （共 7 条）
反应条件
ammonium hydroxide in methanol T=20°C; 1 h;
参考文献
Saloutin; Skryabina; Bazyl'; Kisil'
Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 83 - 90
反应条件
hydrogenchloride; water; acetic acid T=45°C; Hydrolysis; 96 h; Title compound not separated from byproducts;
参考文献
Saloutin; Skryabina; Bazyl'; Kisil'
Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 83 - 90
反应条件
1: ethyl acetoacetate With magnesium diethoxide
T=50°C; 1 h;
2: 2,3,4,5,6-pentafluorobenzoyl chloride in benzene
T=20 - 50°C; 1.25 h;
3: in dimethyl sulfoxide
T=80°C; 3 h;
参考文献
Burgart; Kisil; Saloutin; Chupakhin
Mendeleev Communications, 2001 , vol. 11, # 2 p. 76 - 76
参考文献
Kisil'; Burgart; Saloutin
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 10 p. 1455 - 1462
参考文献
Kisil'; Burgart; Saloutin; Chupakhin
Journal of Fluorine Chemistry, 2001 , vol. 108, # 2 p. 125 - 131
反应条件
1.1: Mg(OEt)2 / 1 h / 50 °C
1.2: benzene / 1.25 h / 20 - 50 °C
1.3: HCl / diethyl ether
2.1: 92 percent / 1 h / 100 - 110 °C
View Scheme
参考文献
Kisil'; Burgart; Saloutin; Chupakhin
Journal of Fluorine Chemistry, 2001 , vol. 108, # 2 p. 125 - 131
反应条件
1.1: Mg(OEt)2 / 1 h / 50 °C
1.2: benzene / 1.25 h / 20 - 50 °C
1.3: HCl / diethyl ether
2.1: 92 percent / 1 h / 100 - 110 °C
View Scheme
参考文献
Kisil'; Burgart; Saloutin; Chupakhin
Journal of Fluorine Chemistry, 2001 , vol. 108, # 2 p. 125 - 131
