1-((2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基)-2,4-二氧代-1,2,3,4-四氢嘧啶-5-甲醛合成路线 （共 24 条）
参考文献
Fan, Xuesen; Zhang, Xinying; Zhou, Longhu; Keith, Kathy A.; Kern, Earl R.; Torrence, Paul F.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3224 - 3228
反应条件
1: methanol / 3 h / 20 °C
2: aq. AcOH / 50 °C
View Scheme
参考文献
Fan, Xuesen; Zhang, Xinying; Zhou, Longhu; Keith, Kathy A.; Kern, Earl R.; Torrence, Paul F.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3224 - 3228
反应条件
1: OsO4, NMO, H2O / acetone; 2-methyl-propan-2-ol
2: TBAF
3: NaIO4, H2O
View Scheme
参考文献
Kittaka, Atsushi; Horii, Chikafumi; Kuze, Tetsuya; Asakura, Takashi; Ito, Katsutoshi; Nakamura, Kazuo T.; Miyasaka, Tadashi; Inoue, Jun-Ichiro
Synlett, 1999 , # SPEC. ISS. p. 869 - 872
反应条件
1: Br2 / 1,2-dichloro-ethane
2: NaHCO3 / H2O
3: 72 percent / CrO3*pyridine; Al2O3; hydrochloric acid / 1,2-dichloro-ethane / 18 h / 25 °C
4: 93 percent / triethylamine / methanol; H2O / 2 h / 20 °C
View Scheme
参考文献
Ivanov; Simonyan; Belanov; Aleksandrova
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 6 p. 556 - 562
反应条件
1: NaHCO3 / H2O
2: 72 percent / CrO3*pyridine; Al2O3; hydrochloric acid / 1,2-dichloro-ethane / 18 h / 25 °C
3: 93 percent / triethylamine / methanol; H2O / 2 h / 20 °C
View Scheme
参考文献
Ivanov; Simonyan; Belanov; Aleksandrova
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 6 p. 556 - 562
反应条件
1: 72 percent / CrO3*pyridine; Al2O3; hydrochloric acid / 1,2-dichloro-ethane / 18 h / 25 °C
2: 93 percent / triethylamine / methanol; H2O / 2 h / 20 °C
View Scheme
参考文献
Ivanov; Simonyan; Belanov; Aleksandrova
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 6 p. 556 - 562
反应条件
1: ruthenium(IV) oxide monohydrate / 1,4-dioxane / 14 h / 110 °C
2: pyridine hydrogenfluoride; pyridine / ethyl acetate / 62 h / 20 °C
View Scheme
参考文献
Schiesser, Stefan; Pfaffeneder, Toni; Sadeghian, Keyarash; Hackner, Benjamin; Steigenberger, Barbara; Schroeder, Arne S.; Steinbacher, Jessica; Kashiwazaki, Gengo; Hoefner, Georg; Wanner, Klaus T.; Ochsenfeld, Christian; Carell, Thomas
Journal of the American Chemical Society, 2013 , vol. 135, # 39 p. 14593 - 14599
反应条件
1: air / aq. buffer / 60 °C / pH 7.4
2: aq. buffer / 60 °C / pH 7.4
View Scheme
参考文献
Schiesser, Stefan; Pfaffeneder, Toni; Sadeghian, Keyarash; Hackner, Benjamin; Steigenberger, Barbara; Schroeder, Arne S.; Steinbacher, Jessica; Kashiwazaki, Gengo; Hoefner, Georg; Wanner, Klaus T.; Ochsenfeld, Christian; Carell, Thomas
Journal of the American Chemical Society, 2013 , vol. 135, # 39 p. 14593 - 14599
反应条件
1: oxygen / aq. buffer / 60 °C / pH 7.4
2: air / aq. buffer / 60 °C / pH 7.4
3: aq. buffer / 60 °C / pH 7.4
View Scheme
参考文献
Schiesser, Stefan; Pfaffeneder, Toni; Sadeghian, Keyarash; Hackner, Benjamin; Steigenberger, Barbara; Schroeder, Arne S.; Steinbacher, Jessica; Kashiwazaki, Gengo; Hoefner, Georg; Wanner, Klaus T.; Ochsenfeld, Christian; Carell, Thomas
Journal of the American Chemical Society, 2013 , vol. 135, # 39 p. 14593 - 14599
反应条件
sodium periodate; water
Yield given;
参考文献
Kittaka, Atsushi; Horii, Chikafumi; Kuze, Tetsuya; Asakura, Takashi; Ito, Katsutoshi; Nakamura, Kazuo T.; Miyasaka, Tadashi; Inoue, Jun-Ichiro
Synlett, 1999 , # SPEC. ISS. p. 869 - 872
