1: 1H-indole-3-carboxylic acid methyl ester With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: 4-bromomethyl-fluorobenzene in N,N-dimethyl-formamide T=20°C; 48 h;

1.1: 86 percent / HCl / 1 h / 65 °C 2.1: NaH / dimethylformamide / 0.5 h / 20 °C 2.2: 56 percent / dimethylformamide / 48 h / 20 °C View Scheme