5-氯-2-(1H-四唑-1-基)苯甲酸合成路线 （共 2 条）
反应条件
sodium azide; acetic acid T=0 - 20°C; 19 h;
参考文献
Howard, Nigel; Abell, Chris; Blakemore, Wendy; Chessari, Gianni; Congreve, Miles; Howard, Steven; Jhoti, Harren; Murray, Christopher W.; Seavers, Lisa C. A.; Van Montfort, Rob L. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1346 - 1355
反应条件
1: 83 percent / N,N-diisopropylethylamine; [(benzotriazol-1-yloxy)tripyrrolidinophosphonium]*PF6 / CH2Cl2 / 36 h
2: 94 percent / LiAlH4 / tetrahydrofuran / 1 h / -78 °C
View Scheme
参考文献
Howard, Nigel; Abell, Chris; Blakemore, Wendy; Chessari, Gianni; Congreve, Miles; Howard, Steven; Jhoti, Harren; Murray, Christopher W.; Seavers, Lisa C. A.; Van Montfort, Rob L. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1346 - 1355
