N-(2-氰基乙基) 甘氨酸乙酯合成路线 （共 9 条）
反应条件
1: CHCl3 2: NaBH4 / ethanol / 0 °C 3: LAH / tetrahydrofuran / -5 °C 4: NaHCO3 / dioxane; H2O View Scheme
参考文献
Hong, Chang Yong; Kim, Young Kwan; Chang, Jay Hyok; Kim, Se Ho; Choi, Hoon; Nam, Do Hyun; Kim, Yong Zu; Kwak, Jin Hwan
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3584 - 3593
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: NaOEt / ethanol / 3 h / Heating 3: 95 percent / NaBH4 / ethanol / 0.5 h / 0 °C View Scheme
参考文献
Hong, Chang Yong; Kim, Young Kwan; Chang, Jay Hyok; Kim, Se Ho; Choi, Hoon; Nam, Do Hyun; Kim, Yong Zu; Kwak, Jin Hwan
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3584 - 3593
反应条件
1: CHCl3 / 17 h / Ambient temperature 2: EtONa/EtOH / 1 h / Heating 3: 100 percent / NaBH4 / ethanol / 0.5 h / 0 °C 4: LiAlH4 / tetrahydrofuran / 0.5 h / -5 °C 5: dioxane; H2O / 0.5 h 6: 85 percent / Et3N, pyridine-SO3, DMSO / 3 h / Ambient temperature 7: 88 percent / hydroxylamine hydrochloride, aq. NaHCO3 / ethanol; tetrahydrofuran / 1 h / 40 °C 8: 94 percent / AcCl, MeOH / 0.83 h / Ambient temperature 9: 85 percent / DBU / acetonitrile / 0.5 h / Ambient temperature View Scheme
参考文献
Hong, Chang Yong; Kim, Young Kwan; Chang, Jay Hyok; Kim, Se Ho; Choi, Hoon; Nam, Do Hyun; Kim, Yong Zu; Kwak, Jin Hwan
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3584 - 3593
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: NaOEt / ethanol / 3 h / Heating View Scheme
参考文献
Guo, Xin; Bai, Xiao-Guang; Li, Yi-Liang; An, Zhi-Jiao; Xu, Le-Xing; Han, Li-You; Liu, Ming-Liang; Guo, Hui-Yuan; Wang, Yu-Cheng
Archiv der Pharmazie, 2011 , vol. 344, # 8 p. 523 - 529
反应条件
1: in chloroform 2: With sodium ethanolate in ethanol Heating;
参考文献
Hong, Chang Yong
Farmaco, 2001 , vol. 56, # 1-2 p. 41 - 44
反应条件
potassium hydroxide in water
T=20°C; Cooling with ice bath;
参考文献
Jahangir, Alam; Lynch, Stephen M.; Soth, Michael; Yang, Hanbiao
Patent: US2011/71179 A1, 2011 ;
Location in patent: Page/Page column 16; 17 ;
反应条件
indium(III) chloride in water
1.) r.t., 10 min, 2.) r.t., 20 h;
参考文献
Loh, Teck-Peng; Wei, Lin-Li
Synlett, 1998 , # 9 p. 975 - 976
参考文献
Terent'ew; Buzkus
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 1230,1232;engl.Ausg.S.1295,1296
反应条件
1: CH2Cl2 / 1 h / 20 °C
2: NaOEt / ethanol / 3 h / Heating
3: 95 percent / NaBH4 / ethanol / 0.5 h / 0 °C
4: LiAlH4 / tetrahydrofuran / -5 °C
View Scheme
参考文献
Hong, Chang Yong; Kim, Young Kwan; Chang, Jay Hyok; Kim, Se Ho; Choi, Hoon; Nam, Do Hyun; Kim, Yong Zu; Kwak, Jin Hwan
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3584 - 3593
