(6-氯-4-(甲基氨基)吡啶-3-基)甲醇合成路线 （共 5 条）
反应条件
manganese(IV) oxide in dichloromethane T=30°C; 6 h;
参考文献
WO2008/33999 A2, ;
Page/Page column 76 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 0.333333 h; Inert atmosphere;
参考文献
FLYNN, Daniel L.; KAUFMAN, Michael D.
Patent: WO2013/184119 A1, 2013 ;
Location in patent: Paragraph 0195 ;
反应条件
1.1: acetonitrile; water / 3.5 h / 0 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C
2.2: 20 °C
View Scheme
参考文献
IRM LLC; NOVARTIS AG; TELLEW, John E.; PAN, Shifeng; WAN, Yongqin; XIE, Yongping; WANG, Xing; WANG, Xia; HUANG, Shenlin; LIU, Zuosheng; ZHANG, Qiong
Patent: WO2011/97526 A1, 2011 ;
WO 2011/097526 A1
反应条件
1.1: acetic anhydride / 1.5 h / 120 °C
1.2: 0 °C / Cooling
1.3: pH < 5
2.1: trichlorophosphate / 3 h / 110 °C
3.1: acetonitrile; water / 3.5 h / 0 - 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C
4.2: 20 °C
View Scheme
参考文献
IRM LLC; NOVARTIS AG; TELLEW, John E.; PAN, Shifeng; WAN, Yongqin; XIE, Yongping; WANG, Xing; WANG, Xia; HUANG, Shenlin; LIU, Zuosheng; ZHANG, Qiong
Patent: WO2011/97526 A1, 2011 ;
WO 2011/097526 A1
反应条件
1.1: trichlorophosphate / 3 h / 110 °C
2.1: acetonitrile; water / 3.5 h / 0 - 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C
3.2: 20 °C
View Scheme
参考文献
IRM LLC; NOVARTIS AG; TELLEW, John E.; PAN, Shifeng; WAN, Yongqin; XIE, Yongping; WANG, Xing; WANG, Xia; HUANG, Shenlin; LIU, Zuosheng; ZHANG, Qiong
Patent: WO2011/97526 A1, 2011 ;
WO 2011/097526 A1
