alpha-酮基异己酸钠盐合成路线 （共 17 条）
反应条件
Zn(ClO4)2; (S)-15-aminomethyl-14-hydroxy-5,5-dimethyl-2,8-dithialt;9gt;(2,5)pyridinophane in methanol-d1 96 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tachibana, Yoji; Ando, Makoto; Kuzuhara, Hiroyoshi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 12 p. 3652 - 3656
反应条件
1: 1.) 1,3-dicyclohexylcarbodiimide (DCC), 2.) 1-hydroxybenzotriazole hydrate (HOBT) / CH2Cl2 2: 67 percent / ammonium acetate / ethanol / 3.5 h / Heating View Scheme
参考文献
Bradbury, Robert H.; Griffiths, David; Rivett, Janet E.
Heterocycles, 1990 , vol. 31, # 9 p. 1647 - 1653
反应条件
phosphate buffer; D-glucose; 2-hydroxyethanethiol; sodium chloride; formate dehydrogenase; NADH-H+; benzoylformate reductase; bovine serum albumin; yeast alcohol dehydrogenase in ethanol; water; toluene T=30°C; 24 h;
参考文献
Yamazaki, Yoshimitsu; Maeda, Hidekatsu
Agricultural and Biological Chemistry, 1986 , vol. 50, # 10 p. 2621 - 2632
反应条件
Multistep reaction.;
参考文献
Pearce; Hammershoi; Harrowfield; Sargeson
Chemical Communications, 2000 , # 24 p. 2431 - 2432
反应条件
Zn(ClO4)2; (S)-15-aminomethyl-14-hydroxy-5,5-dimethyl-2,8-dithialt;9gt;(2,5)pyridinophane in methanol-d1
96 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tachibana, Yoji; Ando, Makoto; Kuzuhara, Hiroyoshi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 12 p. 3652 - 3656
反应条件
1: 4-methyl-2-oxopentanoic acid sodium salt With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=-20 - 20°C; 2 h;
2: benzyl alcohol With triethylamine in dichloromethane
T=0 - 20°C; 18 h;
参考文献
Chiesi Farmaceutici S.p.A.
Patent: US6344457 B1, 2002 ;
Location in patent: Page column 38 ;
US 6344457 B1
反应条件
in chloroform; N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: US5268374 A1, 1993 ;
