2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯合成路线 （共 59 条）
反应条件
1: ethanol / Heating 2: HCl / ethanol / Heating View Scheme
参考文献
Wang, Ke; Li, Jinfeng; Degterev, Alexei; Hsu, Emily; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1455 - 1465
反应条件
T=160 - 180°C; 15 h;
参考文献
Ram; Pandey; Vlietinck
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 7 p. 1277 - 1280
反应条件
sodium 72 h; Heating;
参考文献
Reinecke, Manfred G.; Woodrow, Thomas A.; Brown, E. Sherwood
Journal of Organic Chemistry, 1992 , vol. 57, # 3 p. 1018 - 1021
反应条件
1: 92.5 percent / dioxane / 0.5 h / 110 °C 2: 62 percent / NaOH / methanol; H2O / 3 h / Heating View Scheme
参考文献
Pinkin, L. D.; Dzyubenko, V. G.; Abramenko, P. I.; Shpileva, I. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 3 p. 345 - 352
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 3 p. 410 - 417
参考文献
Sabnis, R. W.; Rangnekar, D. W.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 1027 - 1029
参考文献
Nirogi, Ramakrishna V.S.; Kambhampati, Sastri Rama; Kothmirkar, Prabhakar; Arepalli, Sobhanadri; Pamuleti, Narasimha Reddy G.; Shinde, Anil K.; Dubey
Synthetic Communications, 2011 , vol. 41, # 19 p. 2835 - 2851
反应条件
in formamide T=160°C; 6 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5992 - 5994
反应条件
1: 85 percent / acetic acid / 0.08 h / 110 °C 2: 94 percent / KOH / ethanol / 50 °C 3: 1) PCl5 / 1) benzene, 30 min, 2) water, 30 deg C, 1 h View Scheme
参考文献
Bauer; Heisler; Konigstein
Tetrahedron, 1993 , vol. 49, # 30 p. 6591 - 6604
反应条件
1.1: aq. NaNO2; HCl / dioxane / 0.25 h / -5 °C 1.2: 54 percent / aq. H3PO4 / diethyl ether / 0.5 h / 0 °C 2.1: 97 percent / aq. NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
hydrogenchloride in chloroform 2 h;
参考文献
Perrissin; Favre; Luu Duc; Huguet; Gaultier; Narcisse
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 5 p. 453 - 456
