3,5-二甲基吡咯-2-甲腈合成路线 （共 10 条）
反应条件
T=150 - 800°C; P=0.00750075 Torr; Pyrolysis; Overall yield = 120 mg;
参考文献
Wentrup, Curt; Lan, Nguyen Mong; Lukosch, Adelheid; Bednarek, Pawel; Kvaskoff, David
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 743 - 753
反应条件
copper(l) iodide in 1-methyl-pyrrolidin-2-one
T=100°C; 15 h;
参考文献
Zhang, Lianpeng; Wen, Qiaodong; Jin, Jisong; Wang, Chen; Lu, Ping; Wang, Yanguang
Tetrahedron, 2013 , vol. 69, # 21 p. 4236 - 4240
反应条件
acetic acid; zinc in water
T=80°C;
参考文献
Damke, Jan-Erik; Koenig, Torben; Haake, Gerold; Latos-Grazynski, Lechoslaw; Monltorls, Franz-Peter
Heterocycles, 2011 , vol. 82, # 2 p. 1503 - 1514
反应条件
water; acetic acid; zinc
T=80°C; 0.5 h;
参考文献
Cheng, Lingjiang; Lightner, David A.
Synthesis, 1999 , # 1 p. 46 - 48
反应条件
in N,N-dimethyl-formamide
48 h; Heating;
参考文献
Alberola, Angel; Andres, Jose M.; Gonzalez, Alfonso; Pedrosa, Rafael; Vicente, Martina
Heterocycles, 1990 , vol. 31, # 6 p. 1049 - 1058
反应条件
T=150 - 800°C; P=0.00750075 Torr; Pyrolysis; Overall yield = 120 mg;
参考文献
Wentrup, Curt; Lan, Nguyen Mong; Lukosch, Adelheid; Bednarek, Pawel; Kvaskoff, David
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 743 - 753
反应条件
1: 84 percent / methanol / 1 h / Heating
2: 37 percent / dimethylformamide / 48 h / Heating
View Scheme
参考文献
Alberola, Angel; Andres, Jose M.; Gonzalez, Alfonso; Pedrosa, Rafael; Vicente, Martina
Heterocycles, 1990 , vol. 31, # 6 p. 1049 - 1058
反应条件
T=150 - 800°C; P=0.00750075 Torr; Pyrolysis; Overall yield = 120 mg;
参考文献
Wentrup, Curt; Lan, Nguyen Mong; Lukosch, Adelheid; Bednarek, Pawel; Kvaskoff, David
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 743 - 753
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
1 h;
2: 3,5-dimethyl-1H-pyrrole-2-carbonitrile 3.5 h;
参考文献
TAIHO PHARMACEUTICAL CO., LTD.
Patent: EP1911755 A1, 2008 ;
Location in patent: Page/Page column 29 ;
EP 1911755 A1
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0°C; 0.25 h; Inert atmosphere;
2: 3,5-dimethyl-1H-pyrrole-2-carbonitrile in N,N-dimethyl-formamide
T=10 - 60°C; Inert atmosphere;
参考文献
Damke, Jan-Erik; Koenig, Torben; Haake, Gerold; Latos-Grazynski, Lechoslaw; Monltorls, Franz-Peter
Heterocycles, 2011 , vol. 82, # 2 p. 1503 - 1514
