Boc-N-甲基-L-缬氨酸合成路线 （共 11 条）
反应条件
sodium hydride in tetrahydrofuran T=0 - 23°C; Inert atmosphere;
参考文献
Bronner, Sarah M.; Goetz, Adam E.; Garg, Neil K.
Journal of the American Chemical Society, 2011 , vol. 133, # 11 p. 3832 - 3835
反应条件
water; sodium hydride in tetrahydrofuran T=17 - 20°C; 2 h;
参考文献
Prashad, Mahavir; Har, Denis; Hu, Bin; Kim, Hong-Yong; Repic, Oljan; Blacklock, Thomas J
Organic letters, 2003 , vol. 5, # 2 p. 125 - 128
反应条件
chloro-trimethyl-silane; sodium cyanoborohydride in acetonitrile 0.166667 h; Ambient temperature;
参考文献
Reddy, G. Vidyasagar; Iyengar
Chemistry Letters, 1999 , # 4 p. 299 - 300
反应条件
in tetrahydrofuran; water; ethyl acetate
参考文献
Schering Corporation
Patent: US5739104 A1, 1998 ;
反应条件
triethylamine in 1,4-dioxane; water T=25°C; Yield given;
参考文献
Shin; Otsuka
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 8 p. 2203 - 2210
反应条件
1: NaHCO3 / 2-methyl-propan-2-ol 2: NaH / tetrahydrofuran View Scheme
参考文献
Bronner, Sarah M.; Goetz, Adam E.; Garg, Neil K.
Journal of the American Chemical Society, 2011 , vol. 133, # 11 p. 3832 - 3835
反应条件
1: NaHCO3 / 2-methyl-propan-2-ol 2: NaH / tetrahydrofuran View Scheme
参考文献
Li, Wen-Ren; Peng, Shao-Zheng
Tetrahedron Letters, 1998 , vol. 39, # 40 p. 7373 - 7376
参考文献
Moore,S. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 766 - 772
反应条件
thionyl chloride 16 h; Reflux;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 8, p. 2085 - 2090
反应条件
1: 98 percent / diethyl ether / 0 °C 2: 92 percent / HCl / dioxane / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 16 p. 5542 - 5549
