反应条件
1: 4-chloro-2-fluoro-1-methoxybenzene With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - -55°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - -10°C; 3: With water; ammonium chloride in tetrahydrofuran; n-heptane; ethylbenzene Cooling with ice;
参考文献
Anderson, Kevin W.; Gillespie, Paul; Huby, Nicholas J. S.; Kong, Norman; Roberts, John L.; Rossman, Pamela L.; So, Sung-Sau
Patent: US2011/124686 A1, 2011 ;
Location in patent: Page/Page column 25 ;