3,4,5-三甲氧基苯甲酰氯合成路线 （共 203 条）
反应条件
carbon disulfide; aluminium trichloride
参考文献
Frank; Tarbell
Journal of the American Chemical Society, 1948 , vol. 70, p. 1276
反应条件
sodium hydroxide; thionyl chloride in hexane; dichloromethane; water; toluene
参考文献
Shionogi and Co., Ltd.
Patent: US5488134 A1, 1996 ;
反应条件
sodium hydroxide
T=20°C; Acylation; 2 h;
参考文献
Bespalov; Gorchakova; Dolgo-Saburov; Kuznetsov; Kosmachev; Libman; Podosinovikova; Ramsh; Shelkovnikov
Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 7 p. 361 - 364
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Zhu, Hua-Jie; Pittman Jr., Charles U.
Synthetic Communications, 2003 , vol. 33, # 10 p. 1733 - 1750
反应条件
in dichloromethane
Acylation; 0 deg C, 1 h, 40 deg C, 4 h;
参考文献
Holerca, Marian N.; Percec, Virgil
European Journal of Organic Chemistry, 2000 , # 12 p. 2257 - 2263
参考文献
Quintin, Jerome; Roullier, Catherine; Thoret, Sylviane; Lewin, Guy
Tetrahedron, 2006 , vol. 62, # 17 p. 4038 - 4051
反应条件
1: (i), (ii) KOH
2: (i) ClCO2Et, Et3N, (ii) /BRN= 635882/
3: KOH
View Scheme
参考文献
Byk Gulden Lomberg
Patent: DE2856753 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 175033
反应条件
1: (i) EtOH, (ii) /BRN= 403117/, benzene
2: H2 / Pd / ethanol
View Scheme
参考文献
Kralt,T. et al.
Recueil des Travaux Chimiques des Pays-Bas, 1961 , vol. 80, p. 330 - 357
反应条件
n-butyllithium
1) 2h, -100 deg C, 2) THF, 30 min, -100 deg C and 20 h, room temperature; Yield given. Multistep reaction;
参考文献
Parham; Bradsher; Edgar
Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1057 - 1061
反应条件
1: potassium thioacyanate; 3,4,5-trimethoxy-benzoic acid chloride in acetone
Reflux;
2: 2-nitro-aniline in acetone
T=20°C; Reflux;
参考文献
Saeed, Aamer; Khera, Rasheed Ahmad; Abbas, Naeem; Latif, Muhammad; Sajid, Imran; Floerke, Ulrich
Turkish Journal of Chemistry, 2010 , vol. 34, # 3 p. 335 - 345
