3,4,5-三甲氧基苯甲酰氯合成路线 （共 203 条）
反应条件
in acetone
0.333333 h; Inert atmosphereReflux;
参考文献
Solinas, Antonio; Faure, Helene; Roudaut, Hermine; Traiffort, Elisabeth; Schoenfelder, Angele; Mann, Andre; Manetti, Fabrizio; Taddei, Maurizio; Ruat, Martial
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1559 - 1571
反应条件
1: 2.6 g / pyridine / 0.5 h / 50 - 60 °C
2: 1.3 g / KOH, pyridine / 40 - 45 °C
3: 0.7 g / sodium acetate, gl. acetic acid / 3 h / Heating
4: 0.2 g / H2 / Pd/C
View Scheme
参考文献
Bhardwaj, D. K.; Gupta, A. K.; Jain, R. K.; Munjal, Anita
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 446 - 448
反应条件
1: 82 percent / (i-Pr)2EtN / CH2Cl2 / 1 h / 0 °C
2: 1.) BuLi / 1.) THF/hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 30 min
3: 90.8 percent / 2 N aq HBr / dioxane / 2.5 h / 50 °C
View Scheme
参考文献
Obrecht, Daniel; Weiss, Bettina
Helvetica Chimica Acta, 1989 , vol. 72, p. 117 - 122
反应条件
1: aqueous diethyl ether; pyridine
2: hydrochloric acid / 20 °C / im geschlossenen Rohr
View Scheme
参考文献
Mauthner
Chemische Berichte, 1908 , vol. 41, p. 923
参考文献
Buzas,A. et al.
Chimica Therapeutica, 1972 , vol. 7, p. 135 - 139
反应条件
potassium tert-butylate in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Ozaki; Maeda; Iwasaki; Matsumoto; Odawara; Sasaki; Morita
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4417 - 4424
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
1 h;
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
