3,4,5-三甲氧基苯甲酰氯合成路线 （共 203 条）
反应条件
sodium hydroxide
T=0 - 20°C; Schotten-Baumann method;
参考文献
Davies, John S.; Hakeem, Essam
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 8 p. 1387 - 1392
反应条件
hydrogenchloride in tetrahydrofuran; water
2 h; Ambient temperaturepH 2 to 3.5;
参考文献
Carceller; Almansa; Merlos; Giral; Bartroli; Garcia-Rafanell; Forn
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4118 - 4134
反应条件
in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Kar
Pharmazie, 1983 , vol. 38, # 5 p. 313 - 315
反应条件
1: 2',4',6'-trihydroxyacetophenone With potassium carbonate in acetone
T=20°C; 0.166667 h;
2: 3,4,5-trimethoxy-benzoic acid chloride in acetone
24 h; Heating;
参考文献
Gao, Hong; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2004 , vol. 68, # 9 p. 1858 - 1864
反应条件
1.1: pyridine / 20 °C
2.1: potassium hydroxide / pyridine / 0.33 h / 50 °C
2.2: 0.5 h
2.3: |Reflux
View Scheme
参考文献
Pandurangan
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 225 - 229
反应条件
in pyridine
T=100°C; 1 h;
参考文献
Szantay; Honty; Blasko; et al.
1983 , vol. No. 8, p. 1278 - 1291
反应条件
triethylamine in chloroform-d1
T=0°C; Acylation;
参考文献
Bespalov; Gorchakova; Dolgo-Saburov; Kuznetsov; Kosmachev; Libman; Podosinovikova; Ramsh; Shelkovnikov
Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 7 p. 361 - 364
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Leighty, Matthew W.; Spletstoser, Jared T.; Georg, Gunda I.
Organic Syntheses, 2012 , vol. 88, p. 427 - 437
反应条件
pyridine in dichloromethane
Substitution; 20 h;
参考文献
Keck, Gary E; McLaws, Mark D; Wager, Travis T
Tetrahedron, 2000 , vol. 56, # 51 p. 9875 - 9883
