3,4,5-三甲氧基苯甲酰氯合成路线 （共 203 条）
反应条件
1: 6-methoxy-1H-indole With ethylmagnesium bromide; zinc(II) chloride in diethyl ether; dichloromethane
T=20°C; 1 h;
2: 3,4,5-trimethoxy-benzoic acid chloride With aluminium trichloride in diethyl ether; dichloromethane
5 h;
参考文献
Hsieh, Hsing-Pang; Liou, Jing-Ping; Chang, Jang-Yang; Chang, Chun-Wei
Patent: US2005/267108 A1, 2005 ;
Title/Abstract Full Text Show Details
Hsieh, Hsing-Pang; Liou, Jing-Ping; Chang, Jang-Yang; Chang, Chun-Wei
Patent: US2005/267194 A1, 2005 ;
反应条件
1: calcium oxide; benzene
2: POCl3; toluene
3: aqueous KMnO4; tert-butyl alcohol
View Scheme
参考文献
Reeve; Eareckson
Journal of the American Chemical Society, 1950 , vol. 72, p. 5195
反应条件
1: toluene; hydrogen; palladium-barium sulfate
2: alcohol; KOH-solution / -5 °C / Behandeln des Reaktionsprodukts mit verd. Salzsaeure
3: zinc; sodium amalgam; glacial acetic acid / Reagens4: Alkohol
4: methanol / 100 °C
View Scheme
参考文献
Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263
反应条件
(i) NaH, (ii) /BRN= 403117/; Multistep reaction;
参考文献
Pifferi; Monguzzi; Banfi; Carpi
Farmaco, Edizione Scientifica, 1973 , vol. 28, # 10 p. 818 - 829
参考文献
Pifferi; Monguzzi; Banfi; Carpi
Farmaco, Edizione Scientifica, 1973 , vol. 28, # 10 p. 818 - 829
反应条件
1: toluene; hydrogen; palladium-barium sulfate
2: alcohol; KOH-solution / -5 °C / Behandeln des Reaktionsprodukts mit verd. Salzsaeure
View Scheme
参考文献
Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263
反应条件
1: 1.83 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
2: 72 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Roehnert,H.
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1962 , vol. 295, p. 697 - 706
反应条件
carbon disulfide; aluminium trichloride
参考文献
Spaeth et al.
Chemische Berichte, 1933 , vol. 66, p. 125,129
反应条件
pyridine
Ambient temperature;
参考文献
Buzas,A. et al.
Chimica Therapeutica, 1972 , vol. 7, p. 140 - 142
参考文献
Gensler; Samour
Journal of the American Chemical Society, 1951 , vol. 73, p. 5555
