3,4,5-三甲氧基苯甲酰氯合成路线 （共 203 条）
参考文献
Schloegl,K.; Schloegl,R.
Monatshefte fuer Chemie, 1964 , vol. 95, p. 922 - 941
反应条件
triethylamine in dichloromethane
参考文献
Pifferi; Consonni; Diena; Rosselli del Turco
Journal of medicinal chemistry, 1972 , vol. 15, # 8 p. 851 - 853
反应条件
1: 1) NaOH, 2) 5N HCl / 1) H2O, a) 1 deg C, 3.5h, b) 20 deg C, 1h, 2) 0 deg C
2: 1) Cu(0)/O2/trimethylamine N-oxide, 2) 0.5N HCl / 1) CH3CN, 75 deg C, 50h
3: 15percent aq. H2SO4 / 1) reflux, 2) 3 deg C
View Scheme
参考文献
Reinaud; Capdevielle; Maumy
Synthesis, 1990 , # 7 p. 612 - 614
反应条件
in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Kar
Pharmazie, 1983 , vol. 38, # 5 p. 313 - 315
参考文献
Searle and Co.
Patent: US2852520 , 1957 ;
Full Text Show Details
Searle and Co.
Patent: US2800475 , 1955 ;
参考文献
Sonn; Mueller
Chemische Berichte, 1919 , vol. 52, p. 1930
参考文献
Abdel-Aziz, Mohamed; Beshr, Eman A.; Abdel-Rahman, Islam M.; Ozadali, Keriman; Tan, Oya Unsal; Aly, Omar M.
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 155 - 165
反应条件
1: acetone; water
View Scheme
参考文献
Sugasawa
Yakugaku Zasshi, 1935 , vol. 55, p. 224,228; engl. Ref. S. 58, 59
Chem.Abstr., 1935 , p. 5116
反应条件
pyridine
T=0 - 20°C;
参考文献
Khan, Zulfiqar Ali; Naqvi, Syed Ali Raza; Shahzad, Sohail Anjum; Mahmood, Nasir; Yar, Muhammad; Zahoor, Ameer Fawad
Asian Journal of Chemistry, 2013 , vol. 25, # 1 p. 152 - 156
反应条件
1: 1.) ZnCl2 / 1.) Et2O, reflux, 3 h, 2.) benzene, r.t., overnight
2: 98percent hydrazine hydrate / ethanol / 5 h / Heating
3: KOH / 1 h / 180 °C
4: 75 percent / K / tetrahydrofuran / 24 h / Ambient temperature
View Scheme
参考文献
Azzena, Ugo; Denurra, Teresa; Fenude, Emma; Melloni, Giovanni; Rassu, Gloria
Synthesis, 1989 , # 1 p. 28 - 30
