4,7-二甲氧基-1H-吡咯[2,3-C]吡啶合成路线 （共 10 条）
反应条件
hydrogen; 1 wt Pd/C in ethyl acetate
参考文献
WO2012/106189 A1, ;
Page/Page column 14 ;
反应条件
copper(l) iodide in methanol T=110 - 120°C; 16 h; sealed tube;
参考文献
US2005/209246 A1, ;
Page/Page column 24 ;
反应条件
copper(l) iodide in methanol; toluene T=115°C; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 23 p. 7778 - 7787
反应条件
1: nitric acid; sulfuric acid 2: chloro-trimethyl-silane; sodium nitrite 4: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 5: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
1: chloro-trimethyl-silane; sodium nitrite 3: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 4: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
1: bromine 2: nitric acid; sulfuric acid 3: chloro-trimethyl-silane; sodium nitrite 5: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 6: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
2: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 3: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
1: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 2: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile T=65°C; 3 h;
参考文献
Gesenberg, Kirsten; Deshpande, Prashant P.; Pullockaran, Annie; Xu, Feng; Wu, Dedong; Gao, Qi; Pathirana, Charles; Castoro, John; Soundararajan, Nachimuthu; Staab, Andrew
Tetrahedron Letters, 2007 , vol. 48, # 15 p. 2675 - 2677
反应条件
1: trichlorophosphate
2: 4-Me-2-pentanol
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
