(5R)-5-(2,2-二甲基-4H-1,3-苯并二氧杂环己-6-基)-1,3-恶唑烷-2-酮合成路线 （共 5 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A
Organic and biomolecular chemistry, 2003 , vol. 1, # 7 p. 1106 - 1111
反应条件
triethylamine in chloroform T=20°C;
参考文献
ALMIRALL PRODESFARMA S.A.
Patent: WO2006/122788 A1, 2006 ;
Location in patent: Page/Page column 54 ;
WO 2006/122788 A1
反应条件
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C View Scheme
参考文献
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A
Organic and biomolecular chemistry, 2003 , vol. 1, # 7 p. 1106 - 1111
反应条件
1: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 2: 70 percent / NaH / dimethylformamide / 3 h / 20 °C View Scheme
参考文献
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A
Organic and biomolecular chemistry, 2003 , vol. 1, # 7 p. 1106 - 1111
反应条件
1: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 2: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 3: 70 percent / NaH / dimethylformamide / 3 h / 20 °C View Scheme
参考文献
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A
Organic and biomolecular chemistry, 2003 , vol. 1, # 7 p. 1106 - 1111
