4-甲基-2-(4-(三氟甲基)苯基)吡啶合成路线 （共 4 条）
反应条件
ethylene glycol dimethyl ether; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate in water
Suzuki reaction; 20 h; Inert atmosphereReflux;
参考文献
Hall, Adrian; Elliott, Richard L.; Giblin, Gerard M.P.; Hussain, Ishrut; Musgrave, James; Naylor, Alan; Sasse, Rosemary; Smith, Beverley
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1306 - 1311
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); C31H25F4O5P in 1,4-dioxane
T=110°C; Suzuki-Miyaura cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.
Synlett, 2009 , # 17 p. 2852 - 2856
反应条件
C42H64O4P2Pd in tetrahydrofuran
T=60°C; Kumada-Corriu coupling reaction; 20 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.; Kapdi, Anant R.; Schulzke, Carola
Chemistry - A European Journal, 2010 , vol. 16, # 11 p. 3300 - 3303
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate; lithium chloride in ethanol; toluene
Suzuki coupling; 10 h; Heating;
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
