5-溴吡啶-3-硼酸频哪醇酯合成路线 （共 6 条）
反应条件
1: 3.5-Dibromopyridine With n-butyllithium in diethyl ether T=-78°C; 1 h; 2: With tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether T=20°C; 2 h;
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R.; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 17 p. 3323 - 3328
反应条件
1: 3.5-Dibromopyridine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-78°C; 2.5 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran T=-78 - 20°C;
参考文献
Peters, Martin; Trobe, Melanie; Breinbauer, Rolf
Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2450 - 2456
反应条件
1.1: 2 h / 68 °C 2.1: isopropylmagnesium chloride lithium chloride complex / tetrahydrofuran / 2.5 h / -78 °C 2.2: -78 - 20 °C View Scheme
参考文献
Peters, Martin; Trobe, Melanie; Breinbauer, Rolf
Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2450 - 2456
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=65°C; Suzuki coupling;
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R.; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 17 p. 3323 - 3328
反应条件
pyridine; copper diacetate; 4 A molecular sieve in dichloromethane T=20°C; Chan-Lam coupling; 96 h;
参考文献
Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Lesnard, Aurelien; Rault, Sylvain
Tetrahedron, 2006 , vol. 62, # 25 p. 6000 - 6005
反应条件
dihydrogen peroxide in dichloromethane; water T=20°C; 20 h;
参考文献
Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain
Tetrahedron, 2005 , vol. 61, # 6 p. 1417 - 1421
