2-氟吡啶-3-硼酸频哪酯合成路线 （共 5 条）
反应条件
1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; diethyl ether T=-60°C; 1 h; Inert atmosphere; 2: tri-isopropoxy-borane in tetrahydrofuran; diethyl ether T=-60 - 20°C; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in tetrahydrofuran; diethyl ether T=20°C; Inert atmosphere;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; LI, Jijun; ZHU, Yan; HU, Yuandong; WANG, Huting; WANG, Zhe; WANG, Zanping; WEI, Yongheng; SUN, Yinghui; WU, Qiong; ZHANG, Hui; PENG, Yong; KONG, Fansheng; SUN, Ying; LUO, Hong; HAN, Yongxin
Patent: WO2013/71865 A1, 2013 ;
Location in patent: Page/Page column 27 ;
反应条件
1: 2-fluoro-pyridine With lithium diisopropyl amide in diethyl ether T=-60°C; 0.75 h; 2: With tri-isopropoxy-borane in diethyl ether T=-60 - 20°C; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether T=20°C; 2 h;
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R.; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 17 p. 3323 - 3328
反应条件
magnesium sulfate in diethyl ether T=20°C; 16 h;
参考文献
Watson, Charlotte G.; Aggarwal, Varinder K.
Organic Letters, 2013 , vol. 15, # 6 p. 1346 - 1349
反应条件
1: lithium diisopropylamide / hexane; tetrahydrofuran / -10 - 0 °C 2: hexane; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Alessi, Manlio; Larkin, Andrew L.; Ogilvie, Kevin A.; Green, Laine A.; Lai, Sunny; Lopez, Simon; Snieckus, Victor
Journal of Organic Chemistry, 2007 , vol. 72, # 5 p. 1588 - 1594
反应条件
in tetrahydrofuran; hexane T=0 - 20°C; 1 h;
参考文献
Alessi, Manlio; Larkin, Andrew L.; Ogilvie, Kevin A.; Green, Laine A.; Lai, Sunny; Lopez, Simon; Snieckus, Victor
Journal of Organic Chemistry, 2007 , vol. 72, # 5 p. 1588 - 1594
