1-甲氧基-3-甲基-9h-咔唑合成路线 （共 43 条）
反应条件
1: KOH; Bu4NHSO4 / toluene / 20 °C
2: H2 / Pd/C / 3 h / 20 °C
3: 76 percent / Cu(OAc)2 / CH2Cl2 / 2 h / 20 °C
4: 71 percent / DMF / Pd(OAc)2 / 0.02 h / microwave irradiation
View Scheme
参考文献
Sridharan, Vellaisamy; Martin, Ma. Antonia; Menendez, J. Carlos
Synlett, 2006 , # 15 p. 2375 - 2378
反应条件
1: 76 percent / Cu(OAc)2 / CH2Cl2 / 2 h / 20 °C
2: 71 percent / DMF / Pd(OAc)2 / 0.02 h / microwave irradiation
View Scheme
参考文献
Sridharan, Vellaisamy; Martin, Ma. Antonia; Menendez, J. Carlos
Synlett, 2006 , # 15 p. 2375 - 2378
反应条件
1: H2 / Pd/C / 3 h / 20 °C
2: 76 percent / Cu(OAc)2 / CH2Cl2 / 2 h / 20 °C
3: 71 percent / DMF / Pd(OAc)2 / 0.02 h / microwave irradiation
View Scheme
参考文献
Sridharan, Vellaisamy; Martin, Ma. Antonia; Menendez, J. Carlos
Synlett, 2006 , # 15 p. 2375 - 2378
反应条件
1: 77 percent / K2CO3 / acetone / 2 h / Heating
2: 77 percent / trifluoroacetic acid; trifluoromethanesulfonic acid / 0.25 h / Heating
View Scheme
参考文献
Mal, Dipakranjan; Senapati, Bidyut Kumar; Pahari, Pallab
Tetrahedron, 2007 , vol. 63, # 18 p. 3768 - 3781
反应条件
1: 56 percent / KOH / H2O; methanol / 5 h / Heating
2: 77 percent / K2CO3 / acetone / 2 h / Heating
3: 77 percent / trifluoroacetic acid; trifluoromethanesulfonic acid / 0.25 h / Heating
View Scheme
参考文献
Mal, Dipakranjan; Senapati, Bidyut Kumar; Pahari, Pallab
Tetrahedron, 2007 , vol. 63, # 18 p. 3768 - 3781
反应条件
1: BF3*Et2O / CH2Cl2 / 2.5 h / 160 °C
2: 69 percent / DDQ / benzene / 24 h / Heating
3: 81 percent / aq. NaOH / ethanol / 1 h / 20 °C
4: 95 percent / K2CO3 / acetone / 3 h / 60 °C
5: 73 percent / glacial acetic acid / Pd(OAc)2 / 12 h / 160 °C
6: zinc amalgam / ethanol / Heating
View Scheme
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
反应条件
1: 81 percent / aq. NaOH / ethanol / 1 h / 20 °C
2: 95 percent / K2CO3 / acetone / 3 h / 60 °C
3: 73 percent / glacial acetic acid / Pd(OAc)2 / 12 h / 160 °C
4: zinc amalgam / ethanol / Heating
View Scheme
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
反应条件
1: 69 percent / DDQ / benzene / 24 h / Heating
2: 81 percent / aq. NaOH / ethanol / 1 h / 20 °C
3: 95 percent / K2CO3 / acetone / 3 h / 60 °C
4: 73 percent / glacial acetic acid / Pd(OAc)2 / 12 h / 160 °C
5: zinc amalgam / ethanol / Heating
View Scheme
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
反应条件
1: 95 percent / K2CO3 / acetone / 3 h / 60 °C
2: 73 percent / glacial acetic acid / Pd(OAc)2 / 12 h / 160 °C
3: zinc amalgam / ethanol / Heating
View Scheme
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
反应条件
1: 73 percent / glacial acetic acid / Pd(OAc)2 / 12 h / 160 °C
2: zinc amalgam / ethanol / Heating
View Scheme
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
