1-甲氧基-3-甲基-9h-咔唑合成路线 （共 43 条）
反应条件
1: 85 percent / aq. NaOH / ethanol / 2 h / 60 °C
2: 93 percent / K2CO3 / acetone / 3 h / Heating
3: 71 percent / glacial acetic acid / Pd(OAc)2 / 10 h / 140 °C
View Scheme
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
反应条件
1: 72 percent / NaOMe / dioxane / 45 h / 110 °C
2: 73 percent / water / aq. NaOH / dioxane / 18 h / 110 °C
3: 83 percent / PCC, NaOAc / CH2Cl2 / 2.5 h / Ambient temperature
4: 58 percent / BF3*MeOH / 17 h / Ambient temperature
View Scheme
参考文献
Martin, Tracey; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 235 - 240
反应条件
1: 73 percent / water / aq. NaOH / dioxane / 18 h / 110 °C
2: 83 percent / PCC, NaOAc / CH2Cl2 / 2.5 h / Ambient temperature
3: 58 percent / BF3*MeOH / 17 h / Ambient temperature
View Scheme
参考文献
Martin, Tracey; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 235 - 240
反应条件
hydrogen; palladium on activated charcoal in methanol; formic acid
参考文献
Furukawa, Hiroshi; Wu, Tian-Shung; Ohta, Tomoko
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 4202 - 4205
反应条件
1: palladium dichloride / 1,4-dioxane / 3 h / 60 °C
2: potassium carbonate / acetone / 2.5 h / 60 °C
3: potassium carbonate; palladium diacetate; 2-oxo-3,3-dimethyl-butanoic acid / 14 h / 110 °C
View Scheme
参考文献
Ding, Dong; Lv, Xiaobing; Li, Jian; Qiu, Lin; Xu, Guangyang; Sun, Jiangtao
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 24 p. 4084 - 4088
反应条件
1: palladium dichloride / 1,4-dioxane / 3 h / 60 °C
2: potassium carbonate / acetone / 2.5 h / 60 °C
3: potassium carbonate; palladium diacetate; 2-oxo-3,3-dimethyl-butanoic acid / 14 h / 110 °C
View Scheme
参考文献
Ding, Dong; Lv, Xiaobing; Li, Jian; Qiu, Lin; Xu, Guangyang; Sun, Jiangtao
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 24 p. 4084 - 4088
反应条件
potassium hydroxide in diethylene glycol
T=50°C; 1 h; Yield given;
参考文献
Murakami, Yasuoki; Yokoo, Hiroshi; Watanabe, Toshiko
Heterocycles, 1998 , vol. 49, # 1 p. 127 - 132
反应条件
1: 98 percent / H2SO4
2: 72 percent / NaOMe / dioxane / 45 h / 110 °C
3: 73 percent / water / aq. NaOH / dioxane / 18 h / 110 °C
4: 83 percent / PCC, NaOAc / CH2Cl2 / 2.5 h / Ambient temperature
5: 58 percent / BF3*MeOH / 17 h / Ambient temperature
View Scheme
参考文献
Martin, Tracey; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 235 - 240
反应条件
1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; caesium carbonate / toluene / 40 h / Reflux
2: palladium diacetate; potassium carbonate; 2,2,2-trimethylacetic acid / 14 h / 115 °C
3: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 4.5 h / 20 °C
View Scheme
参考文献
Boerger, Carsten; Kataeva, Olga; Knoelker, Hans-Joachim
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 36 p. 7269 - 7273
反应条件
1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; caesium carbonate / toluene / 40 h / Reflux
2: palladium diacetate; potassium carbonate; 2,2,2-trimethylacetic acid / 14 h / 115 °C
3: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 4.5 h / 20 °C
View Scheme
参考文献
Boerger, Carsten; Kataeva, Olga; Knoelker, Hans-Joachim
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 36 p. 7269 - 7273
