1-甲氧基-3-甲基-9h-咔唑合成路线 （共 43 条）
反应条件
1: 83 percent / PCC, NaOAc / CH2Cl2 / 2.5 h / Ambient temperature
2: 58 percent / BF3*MeOH / 17 h / Ambient temperature
View Scheme
参考文献
Martin, Tracey; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 235 - 240
反应条件
1: 46 percent / Na, naphthalene / tetrahydrofuran / 1 h / -30 °C
2: KOH / bis-(2-hydroxy-ethyl) ether / 1 h / 50 °C
View Scheme
参考文献
Murakami, Yasuoki; Yokoo, Hiroshi; Watanabe, Toshiko
Heterocycles, 1998 , vol. 49, # 1 p. 127 - 132
反应条件
1: K2CO3 / acetone / 7 h / Heating
2: 80 percent / LiAlH4 / CH2Cl2; diethyl ether / 2 h / Ambient temperature
View Scheme
参考文献
Bringmann, Gerhard; Tasler, Stefan; Endress, Heike; Peters, Karl; Peters, Eva-Maria
Synthesis, 1998 , # 10 p. 1501 - 1505
反应条件
boron trifluoride-methanol
17 h; Ambient temperature;
参考文献
Martin, Tracey; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 235 - 240
反应条件
Zn–Hg amalgam in ethanol
Heating;
参考文献
Benavides, Adriana; Peralta, Javier; Delgado, Francisco; Tamariz, Joaquin
Synthesis, 2004 , # 15 p. 2499 - 2504
反应条件
1.1: methanol / 5 h / |Reflux
2.1: magnesium sulphate heptahydrate / dichloromethane; methanol
2.2: 0.07 h / 100 °C / 1551.49 - 2585.81 Torr / |Microwave irradiation
View Scheme
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 91 - 98
反应条件
1.1: sulfuric acid; sodium nitrate / water / 2 h / 0 - 10 °C
2.1: potassium carbonate / acetone / 5 h / |Reflux
3.1: hydrazine hydrate / methanol / 3 h / |Reflux
4.1: sodium nitrite; hydrogenchloride / 0 - 5 °C
4.2: 1 h
5.1: hydrogenchloride; acetic acid / 0.08 h
6.1: methanol / 5 h / |Reflux
7.1: magnesium sulphate heptahydrate / dichloromethane; methanol
7.2: 0.07 h / 100 °C / 1551.49 - 2585.81 Torr / |Microwave irradiation
View Scheme
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 91 - 98
反应条件
1.1: hydrogenchloride; acetic acid / 0.08 h
2.1: methanol / 5 h / |Reflux
3.1: magnesium sulphate heptahydrate / dichloromethane; methanol
3.2: 0.07 h / 100 °C / 1551.49 - 2585.81 Torr / |Microwave irradiation
View Scheme
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 91 - 98
反应条件
Ambient temperature;
参考文献
Martin, Tracey; MoodY, Christopher J.
Tetrahedron Letters, 1985 , vol. 26, # 47 p. 5841 - 5842
反应条件
manganese(IV) oxide; toluene-4-sulfonic acid; Tl(OCOCF3)3
Yield given. Multistep reaction;
参考文献
Knoelker, Hans-Joachim; Bauermeister, Michael
Tetrahedron, 1993 , vol. 49, # 48 p. 11221 - 11236
